Plasma and salivary IgA subclasses and IgM in HIV-1-infected individuals.
Plasma and salivary IgA subclasses and IgM in HIV-1-infected individuals.
复制标题
HIV-1 感染者的血浆和唾液 IgA 亚类和 IgM。
DOI：
10.1023/a:1014435920321
复制
发表时间：
2002
影响因子：
9.1
通讯作者：
Jackson,Susan
中科院分区：
文献类型：
--
作者：
Wu,Xueling;Jackson,Susan
我们研究了人类免疫缺陷病毒-1（HIV-1）感染者腮腺唾液中的伊加和IgM反应。与未感染的对照组相比，唾液分泌型IgA 2水平显着增加，在HIV-1感染的受试者，与更高的水平，在那些谁显示的HIV-1感染的口腔表现。通过酶免疫测定法评估，约三分之二的HIV-1感染者唾液HIV-1特异性伊加抗体检测呈阳性，但唾液IgM抗体检测阴性。HIV-1特异性伊加含量与CD 4计数及血浆病毒载量之间无明显相关性，HIV-1特异性伊加比例与总伊加水平无相关性。经Western blot检测，唾液中抗HIV-1伊加抗体以IgA 1为主。针对HIV-1蛋白质的血浆和唾液伊加的特异性之间的比较显示唾液抗gp 41伊加抗体的情况下，和较低的HIV-1特异性伊加和IgM的反应，确定在唾液中比在血浆中。
We examined IgA and IgM responses in parotid saliva from human immunodeficiency virus-1 (HIV-1)-infected individuals. Compared to the uninfected controls, levels of salivary secretory IgA2 were significantly increased in HIV-1-infected subjects, with higher levels in those who displayed oral manifestations of HIV-1 infection. Assessed by enzyme immunoassay, about two thirds of the HIV-1-infected individuals tested positive for salivary HIV-1-specific IgA antibodies but not for salivary IgM. No clear correlations between the amount of HIV-1-specific IgA and CD4 counts or plasma viral loads were found. The proportions of HIV-1-specific IgA did not correlate with the levels of total IgA. Determined by Western blot, IgA1 accounted for the majority of anti-HIV-1 IgA antibodies in saliva. Comparisons between the specificities of plasma and salivary IgA directed to HIV-1 proteins revealed the absence of salivary anti-gp41 IgA antibodies, and lower HIV-1-specific reactivity of IgA and IgM were determined in saliva than in plasma.