Lateral hypothalamus and sympathetic firing rate.
Lateral hypothalamus and sympathetic firing rate.
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下丘脑外侧和交感神经放电率。
DOI：
10.1152/ajpregu.1988.255.3.r507
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
G. Bray
中科院分区：
文献类型：
--
作者：
T. Sakaguchi;M. Takahashi;G. Bray
交感神经放电率的测量已经作出后，急性微量注射葡萄糖或胰岛素到外侧下丘脑区域，以及消融后，该地区与局部注射金硫代葡萄糖。将葡萄糖注射到外侧下丘脑（LH）中，会导致传出交感神经对肩胛间棕色脂肪组织的放电率出现小幅但显着且呈剂量依赖性的降低。注射胰岛素到同一区域产生了一个非常短暂的增加传出交感神经放电率。通过显微注射和金硫葡萄糖产生的外侧下丘脑的双侧病变比对照动物的LH假注射降低了体重。LH损伤后3、9和24 h基础交感神经放电率增加。在第1天和第3天，射击率也有所增加，但到第7天，射击率已恢复到对照水平。这些数据支持这一假设，LH病变增强交感神经活动，但只有非常有限的调制葡萄糖或胰岛素。
Measurements of sympathetic firing rate have been made after the acute microinjection of glucose or insulin into the lateral hypothalamic area as well as after ablation of this area with locally injected gold thioglucose. Injection of glucose into the lateral hypothalamus (LH) produced a small but significant and dose-dependent reduction in the firing rate of efferent sympathetic nerves to interscapular brown adipose tissue. Injection of insulin into the same region produced a very short-lived increase in efferent sympathetic firing rate. Bilateral lesions in the lateral hypothalamus produced by microinjection and gold thioglucose lowered body weight more than sham injections into the LH of control animals. There was an increase in basal sympathetic firing rate at 3, 9, and 24 h after LH lesions. There was also an increase in firing rate at 1 and 3 days, but by 7 days firing rate had returned to control levels. The data support the hypothesis that LH lesions enhance sympathetic activity but show only very limited modulation by glucose or insulin.