A distinct type of heterochromatin within Drosophila melanogaster chromosome 4

A distinct type of heterochromatin within Drosophila melanogaster chromosome 4
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DOI:
10.1534/genetics.106.066407
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发表时间:
2007-03-01
期刊:
影响因子:
3.3
通讯作者:
Elgin, Sarah C. R.
Elgin, Sarah C. R.
中科院分区:
生物学2区
文献类型:
--
作者:
Haynes, Karmella A.;Gracheva, Elena;Elgin, Sarah C. R.

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对果蝇转录基因沉默的研究表明,4 号染色体的大部分类似于中心周异染色质。然而,位置效应杂色的一些修饰因素,包括 4 号染色体剂量和 SU (VAR) 3-9 丢失,对中心周和远端臂 4 号染色体异染色质的沉默具有不同的影响,从而区分这两种异染色质类型。
Studies of transcriptional gene silencing in Drosophila melanogaster suggest that most of chromosome 4 resembles pericentric heterochromatin. However, some modifiers of position-effect variegation, including chromosome 4 dosage and loss of SU (VAR) 3-9, have different effects on silencing in pericentric vs. distal arm chromosome 4 heterochromatin, distinguishing these two heterochromatin types.