Spontaneous Network Activity and Synaptic Development.
Spontaneous Network Activity and Synaptic Development.
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DOI：
10.1177/1073858413510044
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Kerschensteiner D
中科院分区：
文献类型：
--
作者：
Kerschensteiner D
Throughout development, the nervous system produces patterned spontaneous activity. Research over the last two decades has revealed a core group of mechanisms that mediate spontaneous activity in diverse circuits. Many circuits engage several of these mechanisms sequentially to accommodate developmental changes in connectivity. In addition to shared mechanisms, activity propagates through developing circuits and neuronal pathways (i.e. linked circuits in different brain areas) in stereotypic patterns. Increasing evidence suggests that spontaneous network activity shapes synaptic development in vivo. Variations in activity-dependent plasticity may explain how similar mechanisms and patterns of activity can be employed to establish diverse circuits. Here, I will review common mechanisms and patterns of spontaneous activity in emerging neural networks and discuss recent insights into their contribution to synaptic development.
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