The costs and benefits of brain dopamine for cognitive control
The costs and benefits of brain dopamine for cognitive control
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DOI：
10.1002/wcs.1401
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发表时间：
2016-09-01
影响因子：
3.9
通讯作者：
Cools, Roshan
中科院分区：
文献类型：
--
作者：
Cools, Roshan
认知控制帮助我们通过抵制分心和诱惑来实现目标。众所周知，多巴胺能药物可以增强认知控制。然而，多巴胺能药物在不同情况下的作用存在很大的差异，对某些任务有有益的影响，但对其他任务有不利的影响。这种认知任务需求的差异性背后的机制仍不清楚。我的目标是阐明这种跨任务的多巴胺能药物疗效的差异，超越经典模型，强调多巴胺在前额叶皮层的重要性，认知控制和工作记忆。为此，我建立在认知神经科学的最新进展，突出了多巴胺在成本效益决策中的作用。具体来说，我重新概念化的认知控制不仅涉及前额叶多巴胺，但也调制的成本效益决策纹状体多巴胺。这种方法将帮助我们理解为什么我们有时不能（选择）施加认知控制，同时也确定预测多巴胺能药物对认知控制影响的机制因素。WIREs Cogn Sci 2016，7：317-329。doi：10.1002/wcs.1401有关本文的更多资源，请访问。
Cognitive control helps us attain our goals by resisting distraction and temptations. Dopaminergic drugs are well known to enhance cognitive control. However, there is great variability in the effects of dopaminergic drugs across different contexts, with beneficial effects on some tasks but detrimental effects on other tasks. The mechanisms underlying this variability across cognitive task demands remain unclear. I aim to elucidate this across-task variability in dopaminergic drug efficacy by going beyond classic models that emphasize the importance of dopamine in the prefrontal cortex for cognitive control and working memory. To this end, I build on recent advances in cognitive neuroscience that highlight a role for dopamine in cost-benefit decision making. Specifically, I reconceptualize cognitive control as involving not just prefrontal dopamine but also modulation of cost-benefit decision making by striatal dopamine. This approach will help us understand why we sometimes fail to (choose to) exert cognitive control while also identifying mechanistic factors that predict dopaminergic drug effects on cognitive control. WIREs Cogn Sci 2016, 7:317-329. doi: 10.1002/wcs.1401 For further resources related to this article, please visit the .