Chronic stress in solid tumor development: from mechanisms to interventions.
Chronic stress in solid tumor development: from mechanisms to interventions.
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DOI：
10.1186/s12929-023-00903-9
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发表时间：
2023-01-28
影响因子：
11
通讯作者：
Zou, Zhengzhi
中科院分区：
文献类型：
--
作者：
Yan, Jiajing;Chen, Yibing;Luo, Minhua;Hu, Xinyu;Li, Hongsheng;Liu, Quentin;Zou, Zhengzhi
慢性应激通过神经内分泌系统导致体内激素紊乱。癌症患者在疾病进展和治疗过程中经常会出现反复焦虑和不安，这会加速疾病进展并阻碍治疗效果。最近的研究表明，慢性应激调节的神经内分泌系统分泌激素激活肿瘤细胞中与肿瘤发生相关的许多信号通路。激活的神经内分泌系统不仅作用于肿瘤细胞，还调节周围非癌细胞的存活和代谢变化。目前的临床证据也表明，慢性应激影响癌症治疗的结果。然而，在临床上，对于癌症患者的慢性应激缺乏有效的治疗。在这篇综述中，我们讨论了慢性应激调节肿瘤微环境的主要机制，包括应激激素对肿瘤细胞的功能调节（干细胞样特性、转移、血管生成、DNA损伤积累和抗凋亡）、代谢重编程和免疫逃逸以及瘤周神经调节。基于目前癌症和慢性应激的临床治疗框架，我们还总结了药物和非药物治疗方法，为癌症治疗提供一些方向。
Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggravates disease progression and hinders treatment effects. Recent studies have shown that chronic stress-regulated neuroendocrine systems secret hormones to activate many signaling pathways related to tumor development in tumor cells. The activated neuroendocrine system acts not only on tumor cells but also modulates the survival and metabolic changes of surrounding non-cancerous cells. Current clinical evidences also suggest that chronic stress affects the outcome of cancer treatment. However, in clinic, there is lack of effective treatment for chronic stress in cancer patients. In this review, we discuss the main mechanisms by which chronic stress regulates the tumor microenvironment, including functional regulation of tumor cells by stress hormones (stem cell-like properties, metastasis, angiogenesis, DNA damage accumulation, and apoptotic resistance), metabolic reprogramming and immune escape, and peritumor neuromodulation. Based on the current clinical treatment framework for cancer and chronic stress, we also summarize pharmacological and non-pharmacological therapeutic approaches to provide some directions for cancer therapy.
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影响因子：
16.6
作者：
通讯作者：
--
影响因子：
6.4
作者：
Banerjee J;Papu John AM;Schuller HM
通讯作者：
Schuller HM
DOI：
10.1186/s13058-016-0740-2
发表时间：
2016-08-11
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bussard KM;Mutkus L;Stumpf K;Gomez-Manzano C;Marini FC
通讯作者：
Marini FC
影响因子：
64.8
作者：
Balood, Mohammad;Ahmadi, Maryam;Eichwald, Tuany;Ahmadi, Ali;Majdoubi, Abdelilah;Roversi, Karine;Roversi, Katiane;Lucido, Christopher T.;Restaino, Anthony C.;Huang, Siyi;Ji, Lexiang;Huang, Kai-Chih;Semerena, Elise;Thomas, Sini C.;Trevino, Alexandro E.;Merrison, Hannah;Parrin, Alexandre;Doyle, Benjamin;Vermeer, Daniel W.;Spanos, William C.;Williamson, Caitlin S.;Seehus, Corey R.;Foster, Simmie L.;Dai, Hongyue;Shu, Chengyi J.;Rangachari, Manu;Thibodeau, Jacques;Del Rincon, Sonia, V;Drapkin, Ronny;Rafei, Moutih;Ghasemlou, Nader;Vermeer, Paola D.;Woolf, Clifford J.;Talbot, Sebastien
通讯作者：
Talbot, Sebastien
影响因子：
4.7
作者：
Al-Niaimi, Ahmed;Dickson, Elizabeth L.;Mc Nally, Amy
通讯作者：
Mc Nally, Amy