Depression and sleep: what has the treatment research revealed and could the HPA axis be a potential mechanism?
Depression and sleep: what has the treatment research revealed and could the HPA axis be a potential mechanism?
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DOI：
10.1016/j.copsyc.2019.12.002
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发表时间：
2020-08
影响因子：
5.9
通讯作者：
Asarnow LD
中科院分区：
文献类型：
--
作者：
Asarnow LD
研究表明，失眠的改善在抑郁症状的改善中起着关键作用。根据美国国家心理健康研究所的实验治疗方法，最近的研究重点是确定特定的机制;本手稿旨在审查最近的研究一个潜在的机制，功能障碍的HPA轴，这是一个共同的生物基板抑郁症和失眠症。在过去的五年里，研究表明睡眠障碍与皮质醇反应和压力源后的恢复之间存在关系。同时，抑郁与HPA轴功能关系的研究缺乏一致性，且依赖于HPA轴的测量。需要进行旨在确定睡眠，抑郁和HPA轴功能之间因果关系的实验研究。
Research indicates that insomnia improvement plays a critical role in depression symptom improvement. In line with the National Institute of Mental Health Experimental Therapeutics approach recent research focuses on identifying specific mechanisms; the present manuscript aims to review recent research on one potential mechanism, dysfunction in the HPA axis which is a shared biological substrate of both depression and insomnia. Over the past five years, research demonstrated a relationship between sleep disturbance and cortisol reactivity and recovery following a stressor. Meanwhile, research on the relationship between depression and HPA axis functioning is less consistent and is dependent on measurement of HPA axis. Experimental research that aims to determine a causal pathway between sleep, depression and HPA axis functioning is needed.
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