A phosphate tether-mediated, one-pot, sequential ring-closing metathesis/cross-metathesis/chemoselective hydrogenation protocol.
A phosphate tether-mediated, one-pot, sequential ring-closing metathesis/cross-metathesis/chemoselective hydrogenation protocol.
复制标题
磷酸盐系链介导的一锅连续闭环复分解/交叉复分解/化学选择性氢化方案。
DOI：
10.1021/ol301007h
复制
发表时间：
2012
期刊：
影响因子：
5.2
通讯作者：
Hanson,PaulR
中科院分区：
文献类型：
--
作者：
Venukadasula,PhanindraKM;Chegondi,Rambabu;Suryn,GregoryM;Hanson,PaulR
报道了一种通用的三步，一锅，顺序反应方案，包括闭环复分解，交叉复分解和化学选择性氢化。这种磷酸盐系链介导的过程在没有中间体分离的情况下发生，是化学选择性的，并且由磷酸盐系链固有的立体电子性质控制，其最终起到保持双烯丙基双环磷酸盐的完整性以用于随后的亲核加成的作用。总的来说，该方法可用于有效地产生高级多元醇聚醚醚酮。
A versatile three-step, one-pot, sequential reaction protocol involving ring-closing metathesis, cross-metathesis, and chemoselective hydrogenation is reported. This phosphate tether-mediated process occurs without intermediate isolation, is chemoselective, and is governed by stereoelectronic properties innate to phosphate tethers, which ultimately act to preserve the integrity of the bisallylic, bicyclic phosphate for subsequent nucleophilic additions. Overall, this process can be used to efficiently generate advanced polyol synthons.