Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.
复制标题
DOI：
10.2174/1566524015666150303003028
复制
发表时间：
2015
影响因子：
2.5
通讯作者：
Penzes P
中科院分区：
文献类型：
--
作者：
Gao R;Penzes P
自闭症谱系障碍（ASD）和精神分裂症（SCZ）是具有复杂遗传结构但重叠行为表型的认知障碍，这表明共同的通路扰动。多种证据表明，兴奋性和抑制性活动（E/I不平衡）的不平衡是一种共同的病理生理机制。因此，了解E/I不平衡的分子基础可能会对这些疾病的病因学提供重要的见解，并可能为未来的药物发现发现新的靶点。在这里，我们回顾了关键的遗传，生理，神经病理，功能和通路的研究表明，兴奋/抑制电路的改变是ASD和SCZ发病机制的关键。
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with complex genetic architectures but overlapping behavioral phenotypes, which suggests common pathway perturbations. Multiple lines of evidence implicate imbalances in excitatory and inhibitory activity (E/I imbalance) as a shared pathophysiological mechanism. Thus, understanding the molecular underpinnings of E/I imbalance may provide essential insight into the etiology of these disorders and may uncover novel targets for future drug discovery. Here, we review key genetic, physiological, neuropathological, functional, and pathway studies that suggest alterations to excitatory/inhibitory circuits are keys to ASD and SCZ pathogenesis.