Crossbreeding analysis of the mouse epilepsy.
Crossbreeding analysis of the mouse epilepsy.
复制标题
小鼠癫痫的杂交分析。
作者：
Y. Fueta;S. Matsuoka;T. Mita
通过与C57BL/6小鼠杂交，研究了ddy品系分离的E1小鼠癫痫的遗传控制。用显性偏离的概念解释了P1、F1、F2、B1(F1×E1小鼠)和B2(F1×C57BL/6小鼠)癫痫发作的遗传，以癫痫发作频率、诱发癫痫的轮回次数和癫痫形成周期随种群增长的变化为表型指标。结果表明，小鼠癫痫明显受至少单基因和癫痫活动影响因素(S)或多基因控制。C57BL/6杂交小鼠的等位基因是部分隐性的。毛色基因和性别决定与癫痫分离没有明显的相关性。文中还讨论了癫痫样物质(S)对癫痫发作活动增强的可能作用。
Genetic control of the mouse epilepsy of E1 mouse isolated from ddY strain was investigated by crossbreeding with C57BL/6 mouse. A concept of the dominance deviation was applied for the explanation of the epileptic seizure inheritance in the generations of P1, F1, F2, B1 (F1 X E1 mouse) and B2 (F1 X C57BL/6 mouse), in which initial rate increase of the seizure frequency, seizure-inducing rotation numbers and seizure formative period as a function of the population growth were undertaken to be phenotypic measures. It was conclusive that the mouse epilepsy is apparently under genetic control by at least single gene with the seizure activity influencing factor(s) or by plural genes. Those are partially recessive for the allele assumed in cross-hybridized C57BL/6 mouse. No relevance of the coat color genotype and sex determination to the seizure segregation was observed obviously. Possible existence of epileptic substance(s) responsible for the enhancement of the seizure activity is also discussed.