Unique T cell signatures are associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort.
Unique T cell signatures are associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort.
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在高度暴露的人群中，独特的 T 细胞特征与减少沙眼衣原体再感染有关。
DOI：
10.1101/2023.08.02.551709
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Darville,Toni
中科院分区：
文献类型：
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作者：
Yount,KacyS;Kollipara,Avinash;Liu,Chuwen;Zheng,Xiaojing;O'Connell,CatherineM;Bagwell,Bruce;Wiesenfeld,HaroldC;Hillier,SharonL;Darville,Toni
Chlamydia trachomatis(CT) is the most common bacterial sexually transmitted infection globally. Understanding natural immunity to CT will inform vaccine design. This study aimed to profile immune cells and associated functional features in CT-infected women, and determine immune profiles associated with reduced risk of ascended endometrial CT infection and CT reinfection. PBMCs from CT-exposed women were profiled by mass cytometry and random forest models identified key features that distinguish outcomes. CT+ participants exhibited higher frequencies of CD4+ Th2, Th17, and Th17 DN CD4 T effector memory (TEM) cells than uninfected participants with decreased expression of T cell activation and differentiation markers. No significant differences were detected between women with or without endometrial CT infection. Participants who remained follow-up negative (FU-) showed higher frequencies of CD4 T central memory (TCM) Th1, Th17, Th1/17, and Th17 DN but reduced CD4 TEM Th2 cells than FU+ participants. Expression of markers associated with central memory and Th17 lineage were increased on T cell subsets among FU- participants. These data indicate that peripheral T cells exhibit distinct features associated with resistance to CT reinfection. The highly plastic Th17 lineage appears to contribute to protection. Addressing these immune nuances could promote efficacy of CT vaccines.GRAPHICAL ABSTRACT
