MORPHOLOGICAL EXAMINATION OF INTRAHEPATIC BILE-DUCTS IN HEPATOLITHIASIS
MORPHOLOGICAL EXAMINATION OF INTRAHEPATIC BILE-DUCTS IN HEPATOLITHIASIS
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DOI：
10.1007/bf00749679
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发表时间：
1988-01-01
期刊：
影响因子：
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通讯作者：
NAKANUMA, Y
中科院分区：
文献类型：
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作者：
TERADA, T;NAKANUMA, Y
肝内胆管结石患者肝内胆管壁及其周围可见大量腺体成分。用连续切片重建和粘液组织化学方法对这些腺体成分进行研究。腺体有两种类型：增厚管壁内的腺体(壁内)和管壁外的腺体(壁外)。前者为管状排列的粘液腺，后者为管状肺泡型的浆液腺。两个腺体的粘液腺泡均富含中性、羧化和硫酸盐化粘液糖蛋白。连续切片观察显示，壁内腺与胆管腔直接相通，壁外腺通过各自的管道与胆管腔相通。壁内腺通常与胆管衬里上皮连续，提示它们来自内陷和随后增殖的衬里胆管上皮。壁外腺可能起源于先前存在的胆周腺的增殖。壁内腺和壁外腺分泌的粘液可能与肝内胆管树结石的发生和生长有关。
Numerous glandular elements are characteristically found within and around the intrahepatic bile duct walls in hepatolithiasis. These glandular elements were studied by reconstruction of serial sections and mucus histochemistry. The glands were of two types: glands within the thickened ductal wall (intramural) and those outside the wall (extramural). The former were mucous glands arranged in tubular pattern and the latter seromucous glands arranged in tubuloalveolar pattern. Mucous acini of both glands were rich in neutral, carboxylated and sulfated mucus glycoproteins. Serial section observations showed that the intramural glands communicated with bile duct lumina directly, and the extramural glands with ductal lumina via their own conduits. The intramural glands were usually continuous with the epithelia lining bile ducts, suggesting that they were derived from an invagination and subsequently proliferating epithelium lining bile ducts. The extramural glands may have arisen from a proliferation of the pre-existing peribiliary glands. Hypersecreted mucus from the intramural and extramural glands might be causally related to the development and growth of calculi in the intrahepatic biliary tree.