ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms
ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms
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DOI：
10.1016/j.cellimm.2017.10.007
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Laijun Lai
中科院分区：
文献类型：
--
作者：
Min Su;Yujun Lin;Cheng Cui;Xiaohong Tian;Xiuling Lu;Zhixu He;Laijun Lai
Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced.by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein.(MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors.(TEPs) derived from 129S6SvEv Tac mouse embryonic stem cells (mESCs) prevented the development of EAE. In.this study, we expand our previous studies to show that transplantation of MOG expressing mESC-TEPs derived.from C57BL/6 mice also prevents EAE development. Furthermore, by using a MOG-specific T cell receptor (TCR).transgenic mouse model, we demonstrate that both central and peripheral tolerances are involved in the prevention.of EAE induced by MOG expressing mESC-TEPs. Our results suggest that transplantation of human ESCTEPs.expressing MOG may provide an effective approach for the induction of MOG-specific immune tolerance,.thereby the prevention and treatment of MS.
