Cellular and neurochemical basis of sleep stages in the thalamocortical network
Cellular and neurochemical basis of sleep stages in the thalamocortical network
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DOI：
10.7554/elife.18607
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发表时间：
2016-11-16
期刊：
影响因子：
7.7
通讯作者：
Bazhenov, Maxim
中科院分区：
文献类型：
--
作者：
Krishnan, Giri P.;Chauvette, Sylvain;Bazhenov, Maxim
大脑中神经调质的联合作用与整体大脑状态之间的联系仍然是一个谜。在这项研究中，使用丘脑皮质网络的生物药理学现实模型，我们确定了关键的内在和突触机制，与乙酰胆碱（ACh），GABA和单胺的假定作用，导致初级大脑警觉状态（清醒，非快速眼动睡眠[NREM]和REM睡眠）之间的过渡在一个ultradian周期。使用人类的ECoG记录和猫和小鼠的LFP记录，我们发现在NREM睡眠期间，纺锤波和δ振荡的功率在人类中呈负相关，在动物记录中呈正相关。我们用ACh相对水平的差异来解释这种差异。总的来说，我们的研究揭示了关键的内在和突触机制，通过这些机制，不同的神经调节剂联合作用导致特征性的脑EEG节律和睡眠阶段之间的转换。
The link between the combined action of neuromodulators in the brain and global brain states remains a mystery. In this study, using biophysically realistic models of the thalamocortical network, we identified the critical intrinsic and synaptic mechanisms, associated with the putative action of acetylcholine (ACh), GABA and monoamines, which lead to transitions between primary brain vigilance states (waking, non-rapid eye movement sleep [NREM] and REM sleep) within an ultradian cycle. Using ECoG recordings from humans and LFP recordings from cats and mice, we found that during NREM sleep the power of spindle and delta oscillations is negatively correlated in humans and positively correlated in animal recordings. We explained this discrepancy by the differences in the relative level of ACh. Overall, our study revealed the critical intrinsic and synaptic mechanisms through which different neuromodulators acting in combination result in characteristic brain EEG rhythms and transitions between sleep stages.