TGF-β Mediated Crosstalk Between Malignant Hepatocyte and Tumor Microenvironment in Hepatocellular Carcinoma.
TGF-β Mediated Crosstalk Between Malignant Hepatocyte and Tumor Microenvironment in Hepatocellular Carcinoma.
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DOI：
10.4137/cgm.s14205
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Sahu DK
中科院分区：
文献类型：
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作者：
Gupta DK;Singh N;Sahu DK
在本文中，我们回顾了有关恶性肝细胞及其组织环境通过细胞因子信号传导（此处以转化生长因子-β (TGF-β) 信号传导为代表）相互作用来调节肝细胞癌 (HCC) 的现有文献。我们讨论了肝星状细胞向肌成纤维细胞 (MFB) 转变过程中 TGF-β 信号传导的反应、肿瘤相关巨噬细胞 (TAM) 的募集以及肿瘤相关内皮细胞 (TEC) 的富集。恶性肝细胞还分泌多种因子，例如血小板源性生长因子（PDGF）、血管内皮生长因子（VEGF）和TGF-β。 TGF-β是细胞因子超家族，通过与其他生长因子（表皮生长因子受体（EGFR）、PDGF、成纤维细胞生长因子（FGF）、肝细胞生长因子（HGF）、VEGF）、细胞因子和趋化因子以及细胞外基质（ECM）重塑相互作用来创建肿瘤微环境。因此，HCC肿瘤微环境现在可能被认为是肿瘤进展的重要参与者，与靶向治疗相比，可作为全身治疗的潜在靶点。
In this article, we have reviewed current literature regarding the regulation of hepatocellular carcinoma (HCC) by the interaction of malignant hepatocytes and their tissue environment through cytokine signaling, here represented by transforming growth factor-beta (TGF-β) signaling. We have discussed responses of TGF-β signaling in transition of hepatic stellate cells to myofibroblasts (MFBs), recruitment of tumor-associated macrophages (TAMs), and enrichment of tumor-associated endothelial cells (TECs). The malignant hepatocytes also secrete various factors such as platelet-derived growth factors (PDGFs), vascular endothelial growth factor (VEGF), and TGF-β. TGF-β, a super-family of cytokines, creates tumor microenvironment by interacting through other growth factors (epidermal growth factor receptor (EGFR), PDGF, fibroblast growth factor (FGF), hepatocyte growth factor (HGF), VEGF), cytokines and chemokines, and extracellular matrix (ECM) remodeling. Hence, the HCC tumor microenvironment may now be recognized as an important participant of tumor progression to act as potential target to systemic therapies compared to targeted therapies.