MYASTHENIA GRAVIS: SLEEP QUALITY, QUALITY OF LIFE, AND DISEASE SEVERITY
MYASTHENIA GRAVIS: SLEEP QUALITY, QUALITY OF LIFE, AND DISEASE SEVERITY
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DOI：
10.1002/mus.23296
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发表时间：
2012-08-01
期刊：
影响因子：
3.4
通讯作者：
Jerico Pascual, Ivonne
中科院分区：
文献类型：
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作者：
Hernandez Martinez De Lapiscina, Elena;Erro Aguirre, Maria Elena;Jerico Pascual, Ivonne
引言：有很多关于重症肌无力（MG）的生活质量的研究，其与疾病严重程度的关系已经建立。然而，关于MG睡眠障碍的证据是不确定的。研究方法：采用匹兹堡睡眠质量指数（PSQI）、埃普沃思嗜睡量表（ESS）和MG生活质量15项量表（MG-QOL 15）对54例临床稳定的MG患者进行了睡眠和生活质量调查。结果如下：在59%的患者中观察到的病理性PSQI评分在活动性疾病受试者中比临床缓解患者增加[比值比= 4.3;置信区间95%（1.0-17.6）; P = 0.04]。在临床活动性疾病患者中，我们发现PSQI和MG-QOL 15评分之间存在相关性（r = 0.62; P < 0.001）。结论：我们的研究强调了MG患者中睡眠障碍的高患病率。疾病严重程度可能被认为是患者报告的睡眠障碍的MG特异性风险因素。MG-QOL 15和PSQI应用于评估疾病对睡眠和生活质量的影响。肌肉神经46：174-180，2012
Introduction: There is much research on quality of life in myasthenia gravis (MG), and its relationship to disease severity is well-established. However, evidence regarding sleep disturbance in MG is inconclusive. Methods: To evaluate sleep and quality of life among clinically stable MG patients, 54 subjects were investigated by means of the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and 15-Item-Quality-Of-Life Instrument for MG (MG-QOL15). Results: A pathological PSQI score, which was observed in 59% of patients, was increased in subjects with active disease compared with patients in clinical remission [odds ratio = 4.3; confidence interval 95% (1.0-17.6); P = 0.04]. We found a relationship between PSQI and MG-QOL15 scores in patients with clinically active disease (r = 0.62; P < 0.001). Conclusions: Our study highlights the high prevalence of sleep disturbance among MG patients. Disease severity may be considered to be a MG-specific risk factor for patient-reported sleep disturbance. The MG-QOL15 and PSQI should be used to estimate the impact of the disease on sleep and quality of life. Muscle Nerve 46: 174-180, 2012