Uptake of taurocholate by freshly isolated hepatocytes from fetal and newborn rabbits.
Uptake of taurocholate by freshly isolated hepatocytes from fetal and newborn rabbits.
复制标题
来自胎儿和新生兔的新鲜分离的肝细胞对牛磺胆酸盐的摄取。
DOI：
10.1159/000242097
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Evans,MA
中科院分区：
文献类型：
--
作者：
Bhat,R;Bernstein,MS;Anderson,RJ;Vidyasagar,D;Evans,MA
在出生后早期成熟的显着增加易位的速率常数（米氏常数; Km）牛磺胆酸摄取发生在离体兔肝细胞。这种年龄依赖性变化与牛磺胆酸盐摄取效率降低有关，可能与质膜内受体或其微环境的变化有关。胆酸结合物（牛磺胆酸和甘氨胆酸）是早产儿和新生儿中发现的主要胆汁酸。因此，我们在胎兔和新生兔中发现了牛磺胆酸转运的发育依赖性改变，这是令人感兴趣的。
During early postnatal maturation a significant increase in the rate constant of translocation (Michaelis-Menten constant; Km) for taurocholate uptake occurs in isolated rabbit hepatocytes. This age-dependent change is related to a decrease in the efficiency of uptake for taurocholate and is probably associated with changes in the receptor or its microenvironment within the plasma membrane. Cholic acid conjugates (taurocholic and glycocholic acids) are the predominant bile acids found in the premature and neonatal human. It is therefore of interest that in the fetal and neonatal rabbit we have found a developmentally dependent alteration of taurocholic acid transport.