Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells.
Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells.
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发表时间：
2005
影响因子：
3.1
通讯作者：
Y. Izumida;Takeshi Aoki;D. Yasuda;T. Koizumi;C. Suganuma;Koji Saito;N. Murai;Yoshinori Shimizu;Ken Hayashi;Masanori Odaira;Tomakazu Kusano;M. Kushima;Mitsuo Kudano
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文献类型：
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作者：
Y. Izumida;Takeshi Aoki;D. Yasuda;T. Koizumi;C. Suganuma;Koji Saito;N. Murai;Yoshinori Shimizu;Ken Hayashi;Masanori Odaira;Tomakazu Kusano;M. Kushima;Mitsuo Kudano
最近的研究表明，链脲佐菌素诱导的糖尿病后骨髓细胞移植可以支持胰腺 b 细胞质量的恢复和高血糖的部分逆转。为了解决这个问题，我们检查了 c-Met/肝细胞生长因子 (HGF) 信号通路是否参与骨髓移植 (BMT) 后 B 细胞损伤的恢复。在此模型中，供体来源的骨髓细胞在受体脾、肝、肺、胰腺以及宿主肝细胞中呈 HGF 免疫反应阳性。事实上，血浆HGF水平维持在较高值。BMT组胰腺导管细胞中c-Met表达频率及其增殖活性和分化反应高于PBS处理组，导致内源性胰岛素产生细胞数量增加。 BMT 后诱导 c-Met/HGF 信号通路可促进糖尿病大鼠的胰腺再生。
Recent studies have demonstrated that the transplantation of bone marrow cells following diabetes induced by streptozotocin can support the recovery of pancreatic b-cell mass and a partial reversal of hyperglycemia. To address this issue, we examined whether the c-Met/hepatocyte growth factor (HGF) signaling pathway was involved in the recovery of b-cell injury after bone marrow transplantation (BMT). In this model, donor-derived bone marrow cells were positive for HGF immunoreactivity in the recipient spleen, liver, lung, and pancreas as well as in the host hepatocytes. Indeed, plasma HGF levels were maintained at a high value.The frequency of c-Met expression and its proliferative activity and differentiative response in the pancreatic ductal cells in the BMT group were greater than those in the PBS-treated group, resulting in an elevated number of endogenous insulin-producing cells. The induction of the c-Met/HGF signaling pathway following BMT promotes pancreatic regeneration in diabetic rats.