Efficient construction of the kedarcidin chromophore ansamacrolide
Efficient construction of the kedarcidin chromophore ansamacrolide
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DOI：
10.1021/ol0477374
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发表时间：
2005-01-20
期刊：
影响因子：
5.2
通讯作者：
Hirama, M
中科院分区：
文献类型：
--
作者：
Koyama, Y;Lear, MJ;Hirama, M
通过一个有效的atropselectiveSonogashira耦合步骤的安沙丙内酯框架的kedarcidin发色团的流线型组装。为此，开发了两种新的改进的环戊烯和二炔片段的实用合成方法，其特征在于RCM步骤的催化负载量为0.2mol%和1-PrMgCl/CH（2）l（2）作为从酮合成偕二取代环氧化物的新途径。两者都适用于49-g秤。
The streamlined assembly of the ansamacrolide framework of the kedarcidin chromophore via an efficient atropselective Sonogashira coupling step is described. To this end, two newly improved practical syntheses of the cyclopentene and diyne fragments have been developed, which feature 0.2 mol % catalytic loadings for an RCM step and 1-PrMgCl/CH(2)l(2) as a new entry to gem-disubstituted epoxides from ketones. both being applicable to 49-g scales.