Enhanced visual perception with occipital transcranial magnetic stimulation
Enhanced visual perception with occipital transcranial magnetic stimulation
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DOI：
10.1111/j.1460-9568.2011.07814.x
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发表时间：
2011-10-01
影响因子：
3.4
通讯作者：
Lavie, Nilli
中科院分区：
文献类型：
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作者：
Mulckhuyse, Manon;Kelley, Todd A.;Lavie, Nilli
在枕极进行经颅磁刺激（TMS）可以产生一种闪光（或光幻视）的错觉，这表明了一种兴奋效应。虽然以前报道的单脉冲枕极TMS产生的影响通常是破坏性的，在这里，我们报告的第一个演示的位置特定的促进作用对人类的视觉感知。观察员进行了空间线索定向辨别任务。在两个外围占位符中的一个中呈现定向目标。一个单一的脉冲低于光幻视阈值施加到枕极刺激开始前150或200毫秒被发现，以促进目标的歧视，在对侧相比，同侧视野。在150 ms的时间窗口对侧TMS也放大提示效应，增加了有效线索的促进效应和无效线索的干扰效应。这些结果是第一次显示位置特定的增强视觉感知与单脉冲枕极刺激刺激之前的刺激呈现，这表明，枕刺激可以增强视觉皮层的兴奋性，随后的看法。
Transcranial magnetic stimulation (TMS) over the occipital pole can produce an illusory percept of a light flash (or phosphene), suggesting an excitatory effect. Whereas previous reported effects produced by single-pulse occipital pole TMS are typically disruptive, here we report the first demonstration of a location-specific facilitatory effect on visual perception in humans. Observers performed a spatial cueing orientation discrimination task. An orientation target was presented in one of two peripheral placeholders. A single pulse below the phosphene threshold applied to the occipital pole 150 or 200 ms before stimulus onset was found to facilitate target discrimination in the contralateral compared with the ipsilateral visual field. At the 150-ms time window contralateral TMS also amplified cueing effects, increasing both facilitation effects for valid cues and interference effects for invalid cues. These results are the first to show location-specific enhanced visual perception with single-pulse occipital pole stimulation prior to stimulus presentation, suggesting that occipital stimulation can enhance the excitability of visual cortex to subsequent perception.