FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria
FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria
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DOI：
10.1016/j.canlet.2011.03.009
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发表时间：
2011-07-28
期刊：
影响因子：
9.7
通讯作者：
Peng, Zhihai
中科院分区：
文献类型：
--
作者：
Sun, Hongcheng;Teng, Mujian;Peng, Zhihai
分子生物标志物已被提出来改善患者的选择和移植后的监测，但取得的成果很少。在本研究中，叉头盒M1（FOXM1）的表达和其预后的作用进行了研究，在肝细胞癌（HCC）原位肝移植（奥尔特）治疗。我们发现FOXM1在肿瘤中的显著高水平与HCC的恶性病理特征和奥尔特后的不良结局相关。FOXM1表达的状态与米兰标准相结合，可以使预测更准确，并可能对扩大选择移植候选人的标准特别感兴趣。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Molecular biomarker has been proposed to improve patient selection and post-transplant prognostication, but rare achievement has been made. In the present study, Forkhead box M1 (FOXM1) expression and its prognostic role have been investigated in hepatocellular carcinoma (HCC) treated by orthotopic liver transplantation (OLT). We found that the notably higher level of FOXM1 in tumors was associated with malignant pathological features of HCC and unfavorable outcome after OLT. The status of FOXM1 expression combined with the Milan criteria could make the prognostication more accurate and may be of particular interest for expanding the criteria in selecting transplant candidates. (C) 2011 Elsevier Ireland Ltd. All rights reserved.