Effects of repeated RO 15-1788 administration in benzodiazepine-dependent baboons.
Effects of repeated RO 15-1788 administration in benzodiazepine-dependent baboons.
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重复施用 RO 15-1788 对苯二氮卓依赖狒狒的影响。
DOI：
10.1016/0014-2999(85)90220-1
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发表时间：
1985
影响因子：
5
通讯作者：
Griffiths,RR
中科院分区：
文献类型：
--
作者：
Lamb,RJ;Griffiths,RR
长期暴露于地西泮或三唑仑的狒狒服用苯二氮卓类拮抗剂ro15 -1788后，会出现戒断症状。当每隔1天或3天重复给药时，沉淀的戒断症状减弱。然而，这些狒狒对持续暴露于苯二氮卓类药物的镇静作用仍然有耐受性。虽然对药物激动剂作用的耐受性和身体依赖的发展通常被认为是功能相关的现象，但目前的结果表明，这些可能是苯二氮卓类药物的可分离性质。目前的结果清楚地表明，苯二氮卓类激动剂和拮抗剂的某些作用可以独立调节。
Administration of the benzodiazepine antagonist, Ro 15-1788, to baboons that were chronically exposed to diazepam or triazolam precipitated withdrawal signs. When Ro 15-1788 was administered repeatedly at one or three day intervals, precipitated withdrawal signs were attenuated. However, these baboons remained tolerant to the sedative effects of the doses of benzodiazepines to which they were continously exposed. While tolerance to agonist effects of drugs and development of physical dependence are often thought to be functionally interrelated phenomena, the present results suggest that these may be separable properties of the benzodiazepines. The present results clearly indicate that certain actions of benzodiazepine agonists and antagonists can be indepently regulated.