Josef Klingler's Models of White Matter Tracts: Influences on Neuroanatomy, Neurosurgery, and Neuroimaging
Josef Klingler's Models of White Matter Tracts: Influences on Neuroanatomy, Neurosurgery, and Neuroimaging
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DOI：
10.1227/neu.0b013e318214ab79
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发表时间：
2011-08-01
期刊：
影响因子：
4.8
通讯作者：
Preul, Mark C.
中科院分区：
文献类型：
--
作者：
Agrawal, Abhishek;Kapfhammer, Josef P.;Preul, Mark C.
在20世纪30年代，白质束开始与神经外科相关，特别是在卡哈尔的工作之后。在许多关于白质神经生物学的综述中，约瑟夫·克林格勒(1888-1963)的开创性贡献及其在神经学中的应用被忽视了。1934年，在尤金·路德维希的领导下，在巴塞尔大学，克林格勒开发了一种新的解剖方法，这种方法基于对脑组织的冷冻技术，雄辩地揭示了脑白质束。克林格勒与解剖学家、外科医生和其他科学家合作，他对白质束的模型和解剖可以说是有史以来最优雅的创造。他强调了三维解剖关系，为定义内侧颞叶、边缘、岛叶和丘脑的纤维和功能关系奠定了基础，并为立体定向神经外科的潜力做出了贡献。大约在1947年，克林格勒是瑞士-德国团队的一员，该团队独立地进行了第一批立体定向丘脑切除术，他们的靶向和逻辑基于克林格勒的白质研究，描述了立体定向的各种应用，并展示了克林格勒的工作集成到颅脑拓扑学系统中，用于靶向的口才脑结构的外部定位和丘脑深层核团的刺激。克林格勒的工作重新引起了人们的兴趣，因为它适用于将扩散张量成像的纤维映射范例的结果与实际的解剖学证据相关联。尽管其他人描述了白质束，但没有人像克林格的工作那样对神经科学产生如此大的实际影响。更重要的是，约瑟夫·克林格勒是一位鼓舞人心的导师，影响了神经外科医生、神经科学家和脑成像超过四分之三个世纪。
During the 1930s, white matter tracts began to assume relevance for neurosurgery, especially after Cajal's work. In many reviews of white matter neurobiology, the seminal contributions of Josef Klingler (1888-1963) and their neurological applications have been overlooked. In 1934 at the University of Basel under Eugen Ludwig, Klingler developed a new method of dissection based on a freezing technique for brain tissue that eloquently revealed the white matter tracts. Klingler worked with anatomists, surgeons, and other scientists, and his models and dissections of white matter tracts remain arguably the most elegant ever created. He stressed 3-dimensional anatomic relationships and laid the foundation for defining mesial temporal, limbic, insular, and thalamic fiber and functional relationships and contributed to the potential of stereotactic neurosurgery. Around 1947, Klingler was part of a Swiss-German group that independently performed the first stereotactic thalamotomies, basing their targeting and logic on Klingler's white matter studies, describing various applications of stereotaxy and showing Klingler's work integrated into a craniocerebral topographic system for targeting with external localization of eloquent brain structures and stimulation of deep thalamic nuclei. Klingler's work has received renewed interest because it is applicable for correlating the results of the fiber-mapping paradigms from diffusion tensor imaging to actual anatomic evidence. Although others have described white matter tracts, none have had as much practical impact on neuroscience as Klinger's work. More importantly, Josef Klingler was an encouraging mentor, influencing neurosurgeons, neuroscientists, and brain imaging for more than three quarters of a century.