Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3-CD4+CD45+ cells
Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3-CD4+CD45+ cells
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DOI：
10.1016/s1074-7613(02)00339-4
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发表时间：
2002-07-01
期刊：
影响因子：
32.4
通讯作者：
Kiyono, H
中科院分区：
文献类型：
--
作者：
Fukuyama, S;Hiroi, T;Kiyono, H
鼻咽相关淋巴组织 (NALT) 发育的启动独立于派尔氏淋巴结 (PP) 和外周淋巴结 (PLN) 形成所需的程序化细胞因子级联，细胞因子级联由 IL-7R、LTalpha1beta2/LTbetaR 和 NIK 组成。然而，NALT 的后续组织似乎是由这些细胞因子信号级联反应控制的，因为在那些细胞因子级联缺陷的小鼠中，NALT 结构的成熟通常是不完整的。 NALT 以及 PP 和 PLN 在 Id2(-/-) 小鼠中完全不存在。 NALT器官发生是在CD3(-)CD4(+)CD45(+)细胞过继转移到Id2(-/-)小鼠体内后开始的，这构成了CD3-CD4+CD45+诱导细胞可以为次级淋巴组织发育提供IL-7R-、LTalpha1beta2/LTbetaR-和NIK独立的组织器官发生途径的直接证据。
Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3-CD4+CD45+ inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.