Cancer in the Sami population of Sweden in relation to lifestyle and genetic factors
Cancer in the Sami population of Sweden in relation to lifestyle and genetic factors
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DOI：
10.1007/s10654-008-9232-8
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发表时间：
2008-04-01
影响因子：
13.6
通讯作者：
Damber, Lena
中科院分区：
文献类型：
--
作者：
Hassler, Sven;Sjolander, Per;Damber, Lena
放牧驯鹿的瑞典萨米人癌症发病率较低。本研究的目的是调查一大群瑞典萨米人的癌症风险，其中包括具有不同生活方式和萨米遗传传统的萨米人。 1960 年至 1997 年间，官方国家登记册中确认了 41,721 名萨米人，分为两个亚群——驯鹿放牧萨米人 (RS) 和非驯鹿放牧萨米人 (NRS)。在计算发病率和死亡率时，使用人口统计匹配的非萨米参考人群 (NS) 作为标准。发病率和死亡率数据取自瑞典癌症和死亡原因登记册 1961-2003 年。对于萨米男性来说，患结肠癌、前列腺癌、恶性黑色素瘤和非霍奇金淋巴瘤的风险较低，但患胃癌的风险较高。萨米妇女患胃癌和卵巢癌的风险较高，但患膀胱癌的风险较低。与 NRS 相比，RS 表现出较低的相对癌症风险。 RS 男性的相对风险最低，而 NRS 女性的相对风险最高。采用更西化生活方式的 RS 男性与生活在同一地区的 NS 男性表现出相似的前列腺癌相对风险。大多数癌症风险的差异可能归因于生活方式的差异。结论是，传统的萨米生活方式包含以下元素：可以保护他们免受癌症侵害的饮食内容和身体活动。
The reindeer herding Sami of Sweden have low incidences of cancer. The aim of the present study was to investigate the cancer risk in a large cohort of Swedish Sami, containing Sami with different lifestyle and genetic Sami heritage. A cohort of 41,721 Sami identified in official national registers between 1960 and 1997, was divided into two sub-populations - reindeer herding Sami (RS) and non-reindeer herding Sami (NRS). A demographically matched non-Sami reference population (NS) was used as standard when incidence and mortality ratios were calculated. Incidence and mortality data were obtained from the Swedish Cancer and Cause of Death Registers for the period 1961-2003. For Sami men, lower risks were found for cancers of the colon and prostate, and for malignant melanoma and non-Hodkins lymphoma, but higher for stomach cancer. The Sami women showed higher risks for cancers of the stomach and the ovaries, but lower risk for cancer of the bladder. The RS demonstrated lower relative cancer risks compared with the NRS. The lowest relative risk was found among the RS men, while the highest were observed among the NRS women. The RS men who had adopted a more westernized lifestyle showed a similar relative risk for prostate cancer as that of the NS living in the same region. Most of these differences in cancer risks could probably be ascribed to differences in lifestyle. It is concluded that the traditional Sami lifestyle contains elements, e.g. dietary contents and physical activity that may protect them from developing cancer.