CD133 and membrane microdomains: Old facets for future hypotheses
CD133 and membrane microdomains: Old facets for future hypotheses
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DOI：
10.3748/wjg.v17.i36.4149
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发表时间：
2011-09-28
影响因子：
4.3
通讯作者：
Corbeil, Denis
中科院分区：
文献类型：
--
作者：
Fargeas, Christine A.;Karbanova, Jana;Corbeil, Denis
了解消化道内正常和癌细胞中膜微区的各个方面非常重要，不仅从临床角度来看，而且从我们对细胞转化的基本知识来看。通过研究正常和癌症干细胞相关分子CD 133（CD 133 -1），极化上皮细胞的组织和动力学的新方面已在过去十年中被揭示。它与特定的膜微区的关联在这些情况下是高度相关的，并且也可能提供诊断和/或靶向癌症干细胞的新途径。(C)2011年百世登。All rights reserved.
Understanding all facets of membrane microdomains in normal and cancerous cells within the digestive tract is highly important, not only from a clinical point of view, but also in terms of our basic knowledge of cellular transformation. By studying the normal and cancer stem cell-associated molecule CD133 (prominin-1), novel aspects of the organization and dynamics of polarized epithelial cells have been revealed during the last decade. Its association with particular membrane microdomains is highly relevant in these contexts and might also offer new avenues in diagnosis and/or targeting of cancer stem cells. (C) 2011 Baishideng. All rights reserved.