The effects of iodine blocking following nuclear accidents on thyroid cancer, hypothyroidism, and benign thyroid nodules: design of a systematic review.
The effects of iodine blocking following nuclear accidents on thyroid cancer, hypothyroidism, and benign thyroid nodules: design of a systematic review.
复制标题
核事故后碘阻断对甲状腺癌、甲状腺功能减退症和良性甲状腺结节的影响：系统评价的设计。
DOI：
10.1186/s13643-015-0106-3
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发表时间：
2015-09-24
影响因子：
3.7
通讯作者：
Zeeb H
中科院分区：
文献类型：
--
作者：
Dreger S;Pfinder M;Christianson L;Lhachimi SK;Zeeb H
在放射性碘意外释放的情况下，降低不良健康后果风险的最有效的辐射防护方法之一是施用碘化钾（KI）。虽然世界卫生组织的核事故后碘预防指南建议使用碘化钾，并且在大多数国家的指南中也广泛实施，但由于指南主要基于专家意见和建议，因此缺乏科学证据。因此，本研究将通过系统回顾在意外放射性碘释放的情况下KI给药对甲状腺癌、甲状腺功能减退和良性结节的影响来提供证据。我们将采用标准的系统评价方法来识别合格的研究、数据提取、偏倚风险评估、异质性和数据综合。将在MEDLINE（通过PubMed）和EMBASE中进行电子数据库检索，并涵盖与健康状况、干预和发生/位置相关的三个检索块。我们没有日期或语言限制，但仅限于人类。我们将纳入研究，比较碘化钾给药对暴露于放射性碘释放的人群中甲状腺癌、甲状腺功能减退和良性甲状腺结节的影响。研究的质量将被评分。如果可行，将进行荟萃分析。这项拟议的系统性审查将更新1999年以来的现有世卫组织指南。在放射性碘意外释放到环境中的情况下，碘化钾给药对减少甲状腺癌、甲状腺功能减退和良性甲状腺结节的疗效的新证据将为更新世卫组织核事故后碘预防指南提供依据。PROSPERO CRD 42015024340本文的在线版本（doi：10.1186/s13643 - 015 - 0106 - 3）包含补充材料，可供授权用户使用。
One of the most efficient radiation protection methods to reduce the risk of adverse health outcomes in case of accidental radioactive iodine release is the administration of potassium iodine (KI). Although KI administration is recommended by WHO’s guidelines for iodine prophylaxis following nuclear accidents and is also widely implemented in most national guidelines, the scientific evidence for the guidelines lacks as the guidelines are mostly based on expert opinions and recommendations. Therefore, this study will provide evidence by systematically reviewing the effects of KI administration in case of accidental radioactive iodine release on thyroid cancer, hypothyroidism, and benign nodules. We will apply standard systematic review methodology for the identification of eligible studies, data extraction, assessment of risk of biases, heterogeneity, and data synthesis. The electronic database search will be conducted in MEDLINE (via PubMed) and EMBASE, and covers three search blocks with terms related to the health condition, intervention, and occurrence/location. We have no date or language restrictions, but restrictions to humans only. We will include studies comparing the effects of KI administration on thyroid cancer, hypothyroidism, and benign thyroid nodules in a population exposed to radioactive iodine release. The quality of the studies will be graded. If feasible, a meta-analysis will be conducted. This proposed systematic review will update the existing WHO guideline from 1999. New evidence on the efficacy of KI administration to reduce thyroid cancer, hypothyroidism, and benign thyroid nodules in the event of an accidental release of radioactive iodine to the environment will provide the basis for an update of the WHO guideline for iodine prophylaxis following nuclear accidents. PROSPERO CRD42015024340 The online version of this article (doi:10.1186/s13643-015-0106-3) contains supplementary material, which is available to authorized users.