Inherent maternal type 2 immunity: Consequences for maternal and offspring health.
Inherent maternal type 2 immunity: Consequences for maternal and offspring health.
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DOI：
10.1016/j.smim.2021.101527
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发表时间：
2021-11
影响因子：
7.8
通讯作者：
M. Taylor;Jamie Pillaye;W. Horsnell
中科院分区：
文献类型：
--
作者：
M. Taylor;Jamie Pillaye;W. Horsnell
2型免疫的固有升高是母亲和后代免疫系统的特征。这对母亲和后代的生物学有多种影响，包括影响怀孕的成功、后代的免疫发育以及母亲和后代控制感染和过敏等疾病的能力。在这篇综述中，我们提供了一个广泛的见解，如何怀孕和早期生活的免疫特征影响母亲和后代生物学。我们还建议如何理解这个免疫影响轴是和可能用于改善母亲和后代的健康。
An inherent elevation in type 2 immunity is a feature of maternal and offspring immune systems. This has diverse implications for maternal and offspring biology including influencing success of pregnancy, offspring immune development and maternal and offspring ability to control infection and diseases such as allergies. In this review we provide a broad insight into how this immunological feature of pregnancy and early life impacts both maternal and offspring biology. We also suggest how understanding of this axis of immune influence is and may be utilised to improve maternal and offspring health.