ORIGIN OF ANTIBODY VARIATION
ORIGIN OF ANTIBODY VARIATION
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DOI：
10.1038/211242a0
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发表时间：
1966-01-01
期刊：
影响因子：
64.8
通讯作者：
MILSTEIN, C
中科院分区：
文献类型：
--
作者：
BRENNER, S;MILSTEIN, C
超突变理论提出了一种机制，该机制使得突变行为局限于少数基因的特定区域。编码恒定区的基因的核苷酸序列作为一种酶的识别位点，这种酶可切割DNA。在对该局部区域进行修复时，会以较高的随机错误率引入错误，从而产生大量不同的序列。
The hypermutation theory suggest a mechanism which allows the mutational acts to be restricted to specific regions of a few genes. The nucleotide sequence of the gene specifying the invariable region acts as a recognition site for an enzyme which cuts the DNA. During repair of this local region errors are introduced at random at a high rate to generate a large number of different sequences.