A Neo-Sex Chromosome That Drives Postzygotic Sex Determination in the Hessian Fly (Mayetiola destructor)
A Neo-Sex Chromosome That Drives Postzygotic Sex Determination in the Hessian Fly (Mayetiola destructor)
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DOI：
10.1534/genetics.109.108589
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发表时间：
2010-03-01
期刊：
影响因子：
3.3
通讯作者：
Stuart, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Benatti, Thiago R.;Valicente, Fernando H.;Stuart, Jeffrey J.
两个不重叠的常染色体倒位定义不寻常的neo-sex染色体在黑森蝇（Mayetiola destructor）。像其他新性染色体一样，这些染色体通常是杂合的，只存在于一种性别中，并抑制了性别决定主开关周围的重组。它们不寻常的性质起源于异常的黑森蝇性别决定系统，其中合子后染色体消除被用来建立性别决定核型。这个系统允许进化出一个母源性的主开关（染色体维持，Cm）。携带Cm相关性染色体的雌性的所有后代获得雌性决定的体细胞核型并发育为雌性。因此，染色体作为母体效应新W染色体或W-主（W '）染色体，其中ZW'雌性与ZZ雄性交配以产生相等数量的雌性生产（ZW '）和雄性生产（ZZ）雌性。遗传作图和物理作图鉴定了倒位。它们的分布在9个种群中确定。实验交配建立了关联的倒位与厘米和测量其重组抑制。倒位的功能相当于sciarid的X染色体。我们推测W'染色体存在于产生单性育雏的各种物种中。
Two nonoverlapping autosomal inversions defined unusual neo-sex chromosomes in the Hessian fly (Mayetiola destructor). Like other neo-sex chromosomes, these were normally heterozygous, present only in one sex, and suppressed recombination around a sex-determining master switch. Their unusual properties originated from the anomalous Hessian fly sex determination system in which postzygotic chromosome elimination is used to establish the sex-determining karyotypes. This system permitted the evolution of a master switch (Chromosome maintenance, Cm) that acts maternally. All of the offspring of females that carry Cm-associated neo-sex chromosomes attain a female-determining somatic karyotype and develop as females. Thus, the chromosomes act as maternal effect neo-W's, or W-prime (W') chromosomes, where ZW' females mate with ZZ males to engender female-producing (ZW') and male-producing (ZZ) females in equal numbers. Genetic mapping and physical mapping identified the inversions. Their distribution was determined in nine populations. Experimental matings established the association of the inversions with Cm and measured their recombination suppression. The inversions are the functional equivalent of the sciarid X-prime chromosomes. We speculate that W' chromosomes exist in a variety of species that produce unisexual broods.