Tissue engineering of bone and cartilage
Tissue engineering of bone and cartilage
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DOI：
10.1138/20090406
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发表时间：
2009-11
期刊：
影响因子：
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通讯作者：
Shinsuke Ohba;Fumiko Yano;U. Chung
中科院分区：
文献类型：
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作者：
Shinsuke Ohba;Fumiko Yano;U. Chung
在脊椎动物中，骨骼在活动性、运动、钙稳态、造血和保护中具有关键作用。因此，不可逆的骨骼缺陷往往会导致相当大的发病率。组织工程作为治疗不可逆组织缺损的一种有前途的策略已引起人们的关注。组织工程有三个重要的支柱：细胞来源，信号因子和支架。自20世纪90年代后期以来，随着干细胞生物学、骨和软骨生物学以及材料科学的进展，骨和软骨的组织工程沿着取得了实质性进展。特别是，自体细胞植入结合生物可降解支架已被广泛研究。本文综述了骨与软骨组织工程领域的最新进展和目前面临的主要障碍。它包括组织工程的每个支柱的讨论，重点是几个临床前和临床研究，在这一领域的里程碑，并建议未来的前景和方向。IBMS BoneKey。2009年11月;6（11）：405-419。©2009国际骨与矿物学会
In vertebrates, the skeleton has pivotal roles in mobility, locomotion, calcium homeostasis, hematopoiesis and protection. Therefore, irreversible skeletal defects often incur considerable morbidity. Tissue engineering has drawn attention as a promising strategy for the treatment of irreversible tissue defects. There are three pillars important for tissue engineering: cell sources, signaling factors, and scaffolds. Since the late 1990s, substantial progress has been made in tissue engineering of bone and cartilage along with advances in stem cell biology, bone and cartilage biology, and materials science. In particular, autologous cell implantation combined with biodegradable scaffolds have been extensively researched. This Perspective aims to review recent advances and major obstacles currently faced by the field of tissue engineering of bone and cartilage. It includes discussion of each pillar of tissue engineering, with a focus on several preclinical and clinical studies that are milestones in this field, and suggests future perspectives and directions. IBMS BoneKEy. 2009 November;6(11):405-419. ©2009 International Bone & Mineral Society