Higher in vitro susceptibility of human T cells to H5N1 than H1N1 influenza viruses
Higher in vitro susceptibility of human T cells to H5N1 than H1N1 influenza viruses
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DOI：
10.1016/j.bbrc.2008.04.123
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发表时间：
2008-07-04
影响因子：
3.1
通讯作者：
Sawanpanyalert, Pathom
中科院分区：
文献类型：
--
作者：
Li, Yong-Gang;Thawatsupha, Pranee;Sawanpanyalert, Pathom
感染H5N1甲型流感病毒的患者具有严重或致命的后果，表现出包括淋巴细胞减少在内的几种特征性临床表现。在这项研究中，检测了人类CD4(+) t细胞系和健康供者外周血单个核细胞（PBMCs）对泰国H5N1分离株感染的易感性，并与H1N1分离株进行了比较。尽管t细胞系和pbmc中H5N1和H1N1的细胞水平不同，但H5N1感染中子代病毒粒子的产生率明显更高，这表明病毒粒子的释放更有效。此外，PBMCs的细胞致病性，导致CD4(+) t细胞数量下降，H5N1比H1N1严重得多。因此，人类T细胞可能是H5N1感染的重要靶点。(C) 2008爱思唯尔公司版权所有。
Patients infected with H5N1 influenza A virus, who had a severe or fatal outcome, exhibited several characteristic clinical manifestations including lymphopenia. In this study, human CD4(+) T-cell lines and healthy donor-derived peripheral blood mononuclear cells (PBMCs) were examined for susceptibility to infection with Thai isolates of H5N1 in comparison to those of H1N1. Although cellular levels were variable between H5N1 and H1N1 in T-cell lines and PBMCs, rates of production of progeny virions were significantly higher in H5N1 infections, suggesting a more efficient release of virions. In addition, cytopathogenicity in PBMCs, leading to a decline in CD4(+) T-cell numbers, were much severer with H5N1 than H1N1. Thus, human T cells could be an important target for infection with H5N1. (C) 2008 Elsevier Inc. All rights reserved.