Statin collagen grafts used to repair defects in the parietal bone of rabbits
Statin collagen grafts used to repair defects in the parietal bone of rabbits
复制标题
DOI：
10.1016/s0266-4356(03)00081-0
复制
发表时间：
2003-08-01
影响因子：
1.8
通讯作者：
Rabie, ABM
中科院分区：
文献类型：
--
作者：
Wong, RWK;Rabie, ABM
我们比较了他汀类胶原蛋白移植和胶原蛋白移植产生的新骨量。对9只新西兰大白兔的顶骨进行了15个骨缺损的修复。实验组采用辛伐他汀注射液与可吸收性胶原蛋白海绵混合移植5个缺损。对照组5个缺损单独用注射用水混合可吸收胶原蛋白海绵进行移植（主动对照组），空白5个缺损（被动对照组）。第14天处死动物，对缺陷进行组织学检查。在整个缺陷上进行连续切片切割。用图像分析方法对100块切片进行新骨形成定量分析。他汀类胶原蛋白移植的缺损新生骨比单纯胶原蛋白移植的缺损新生骨多308% （P < 0.0001）。被动对照组无骨形成。综上所述，他汀类胶原蛋白具有骨诱导作用，可作为骨移植材料。(C) 2003英国口腔颌面外科医师协会。Elsevier Ltd.出版。版权所有。
We compared the amount of new bone produced by statin collagen grafts with that produced by collagen grafts. Fifteen bone defects were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, five defects were grafted with simvastatin dissolved in water for injection mixed with absorbable collagen sponge. In the control groups, five defects were grafted with water for injection mixed with absorbable collagen sponge alone (active control) and five were left empty (passive control). Animals were killed on day 14 and the defects were prepared for histological assessment. Serial sections were cut across the whole defect. Quantitative analysis of new bone formation was made on 100 sections using image analysis. A total of 308% more new bone was present in defects grafted with statin collagen grafts than those grafted with collagen grafts alone (P < 0.0001). No bone was formed in the passive control group. In conclusion, statin collagen grafts were osteoinductive and can be used as a material for bone grafts. (C) 2003 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.