Myocardial risk area and peak gray level measurement by contrast echocardiography: effect of microbubble size and concentration, injection rate, and coronary vasodilation.
Myocardial risk area and peak gray level measurement by contrast echocardiography: effect of microbubble size and concentration, injection rate, and coronary vasodilation.
复制标题
通过对比超声心动图测量心肌危险区域和峰值灰度：微泡大小和浓度、注射速率和冠状血管舒张的影响。
DOI：
10.1016/0002-8703(88)90872-1
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发表时间：
1988
影响因子：
4.8
通讯作者：
Kerber,RE
中科院分区：
文献类型：
--
作者：
Vandenberg,BF;Feinstein,SB;Kieso,RA;Hunt,M;Kerber,RE
在二维超声心动图成像过程中，通过冠状动脉内途径在8只犬中注射造影剂，以确定微泡大小和浓度、注射速率和冠状动脉血管舒张对危险区域和峰值灰度测量的影响。在13 cc/sec的注射速率下，手动搅拌泛影葡胺/泛影酸钠的平均背景扣除峰值灰度强度显著高于手动搅拌泛影葡胺/泛影酸钠+0.9%盐水、超声处理泛影葡胺/泛影酸钠和超声处理70%山梨醇的平均背景扣除峰值灰度强度（p< 0.01）。通过使用38 cc/sec的注射速率和冠状动脉内注射腺苷消除了这些差异。通过面积测定法评估的灌注面积测定不受所用造影剂、注射速率或冠状动脉内腺苷给药的影响。我们的结论是，通过超声造影技术测量的危险区域不受不同的造影剂，注射速率，或血管舒张的影响。然而，峰值灰度强度在造影剂之间是可变的，并且可能导致时间-活性曲线分析的可变性。
Contrast agents were injected via the intracoronary route in eight dogs during two-dimensional echocardiographic imaging to determine the influence of microbubble size and concentration, injection rate, and coronary vasodilation on risk area and peak gray level measurement. At an injection rate at 13 cc/sec, the average background-subtracted peak gray level intensity of hand-agitated diatrizoate meglumine/diatrizoate sodium was significantly (p< 0.01) higher than that of hand-agitated diatrizoate meglumine/diatrizoate sodium + 0.9% saline, sonicated diatrizoate meglumine/diatrizoate sodium, and sonicated 70% sorbitol. These differences were abolished by the use of 38 cc/sec injection rates and intracoronary injection of adenosine. Perfusion area determinations as assessed by planimetry were unaffected by the contrast agent used, the injection rate, or by intracoronary administration of adenosine. We conclude that risk area measurement by the ultrasound contrast technique is not affected by varying contrast agents, injection rates, or vasodilation. However, peak gray level intensity is variable among contrast agents and may result in variability of time-activity curve analysis.