Expression of the δ-protocadherin gene Pcdh19 in the developing mouse embryo
Expression of the δ-protocadherin gene Pcdh19 in the developing mouse embryo
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DOI：
10.1016/j.modgep.2006.03.001
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发表时间：
2006-10-01
影响因子：
1.2
通讯作者：
Bouchard, Maxime
中科院分区：
文献类型：
--
作者：
Gaitan, Yaned;Bouchard, Maxime
原钙粘蛋白是跨膜蛋白的一个大家族，主要参与脑和其他组织的弱亲同性粘附。在筛选肾脏发育的潜在调节因子时，我们发现了Pcdh19，这是8-原钙粘蛋白亚家族中一个特征不明确的成员。在此，我们报道了Pcdh19在小鼠胚胎发育过程中的时空表达模式。在妊娠中期胚胎中，Pcdh19 mRNA在中肾和前脑、中脑神经上皮中检测到。在后期，Pcdh19在神经视网膜、鼻上皮、脊髓等其他神经组织以及后肾的集管和分化肾、腺胃、外分泌胰腺和毛囊中表达。因此，Pcdh19基因在小鼠器官发生过程中受到发育调控，并在原钙粘蛋白中显示出独特的表达谱。(c) 2006 Elsevier B.V.版权所有
Protocadherins constitute a large family of transmembrane proteins primarily involved in weak homophilic adhesion in the brain and several other tissues. In a screen for potential regulators of kidney development, we have identified Pcdh19, a poorly characterized member of the 8-protocadherin subfamily. Here, we report the spatio-temporal expression pattern of Pcdh19 during mouse embryonic development. In midgestation embryos, Pcdh19 mRNA was detected in the mesonephros and in the neuroepithelium of the forebrain and midbrain. At later stages, Pcdh19 was expressed in other neural tissues such as the neural retina, nasal epithelium and spinal cord, as well as in the collecting duct and differentiating nephrons of the metanephros, in the glandular stomach, the exocrine pancreas and the hair follicles. Hence, the Pcdh19 gene is developmentally regulated during mouse organogenesis and shows a unique expression profile among protocadherins. (c) 2006 Elsevier B.V. All rights reserved.