Suboptimal outcome of management of metabolic cardiovascular risk factors in Hispanic patients with essential hypertension.
Suboptimal outcome of management of metabolic cardiovascular risk factors in Hispanic patients with essential hypertension.
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西班牙裔原发性高血压患者代谢性心血管危险因素管理的结果不佳。
DOI：
10.1161/01.hyp.26.6.1079
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发表时间：
1995
期刊：
影响因子：
8.3
通讯作者：
F. Elijovich
中科院分区：
文献类型：
--
作者：
C. Laffer;F. Elijovich
我们研究了155名随机选择的西班牙裔高血压患者（平均年龄63 +/- 1岁，79%为女性）的代谢心血管危险因素的管理结果。65%的患者存在高甘油三酯血症（n = 12）或高风险调整低密度脂蛋白胆固醇（n = 89）。甘油三酯在2.2 +/- 0.5年期间没有变化（6.16 +/- 0.58至7.44 +/- 2.34 mmol/L; P = NS）。只有58例高LDL-C患者接受了治疗，其中8例没有进行后续的脂质检测。在另外50例患者中，LDL-C在2.8 +/- 0.2年期间下降了10 +/- 3% (P < 0.001)，但只有12例患者达到了目标。在24例延长随访（3.8 +/- 0.2年）的患者中，LDL-C最初显著下降，随后反弹至基线水平。在54例LDL-C正常的患者中，有29例与推荐值相比，脂质检测明显过度使用。在2.7 +/- 0.3年的重复数据（+0.6 +/- 0.8 kg; P = NS; n = 40）中，肥胖（n = 94,61%）没有改善。63例II型糖尿病患者中有44例重复测量糖化血红蛋白，在2.2 +/- 0.3年期间没有变化（10.5 +/- 0.5%至11.2 +/- 0.5%;P = NS）。61例已知血压未经治疗（169 +/- 3/98 +/- 1 mm Hg）的患者10年冠状动脉事件风险（Framingham队列参数回归）为21.0 +/- 1.7%，偏态分布达到高值（66%），大部分可归因于可改变的危险因素（72%）。（摘要删节250字）
We studied outcome of management of metabolic cardiovascular risk factors in 155 randomly chosen Hispanic hypertensive patients (mean age, 63 +/- 1 years; 79% female) screened for dyslipidemia. Hypertriglyceridemia (n = 12) or high risk-adjusted low-density lipoprotein cholesterol (LDL-C) (n = 89) was found in 65%. Triglycerides did not change (6.16 +/- 0.58 to 7.44 +/- 2.34 mmol/L; P = NS) over 2.2 +/- 0.5 years. Only 58 patients with high LDL-C were treated, and 8 had no follow-up lipid tests. In the other 50, LDL-C decreased by 10 +/- 3% (P < .001) over 2.8 +/- 0.2 years but attained goal in only 12. In a subset of 24 patients with extended follow-up (3.8 +/- 0.2 years), there was an initial marked decline in LDL-C, followed by a rebound to baseline levels. In 29 of 54 patients with normal LDL-C, lipid testing was markedly overused compared with recommendations. Obesity (n = 94, 61%) did not improve in those with repeated data (+0.6 +/- 0.8 kg; P = NS; n = 40) over 2.7 +/- 0.3 years. Forty-four of 63 patients with type II diabetes had repeated measurement of glycosylated hemoglobin, with no change (10.5 +/- 0.5% to 11.2 +/- 0.5%; P = NS) over 2.2 +/- 0.3 years. Ten-year risk of coronary events (Framingham cohort parametric regression) calculated for 61 patients with known untreated blood pressures (169 +/- 3/98 +/- 1 mm Hg) was 21.0 +/- 1.7%, with a skewed distribution reaching high values (66%) and attributable in large part (72%) to modifiable risk factors.(ABSTRACT TRUNCATED AT 250 WORDS)
墨西哥裔美国人的高血压患病率降低。
DOI：
10.1161/01.hyp.16.3.225
发表时间：
1990
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Haffner,SM;Mitchell,BD;Stern,MP;Hazuda,HP;Patterson,JK
通讯作者：
Patterson,JK