Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality
Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality
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DOI：
10.1021/acs.cgd.1c00659
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发表时间：
2021-07-30
影响因子：
3.8
通讯作者：
Damodaran, Krishna K.
中科院分区：
文献类型：
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作者：
Jayabhavan, Sreejith Sudhakaran;Steed, Jonathan W.;Damodaran, Krishna K.
合成了一系列具有类似于药物甲硝唑的互补官能团的双（尿素）化合物和结构异构体异美硝唑。研究了这些化合物在不同溶剂/溶剂混合物中的凝胶特性。用流变学方法比较了同分异构体凝胶的机械强度，并用扫描电镜分析了干凝胶的形貌。这些凝胶被用作甲硝唑结晶的介质，导致药物模拟凝胶中甲硝唑晶体的明显习惯改变。然而，非模拟异构体凝胶的结晶导致了与溶液状态相似的形态。这些结果表明，模拟药物凝胶与药物晶体表面相互作用，产生新的形态。
A series of bis(urea) compounds with complementary functional groups similar to the pharmaceutical drug metronidazole and a structural isomer isometronidazole have been synthesized. The gelation properties of these compounds were studied in various solvent/solvent mixtures. The mechanical strength of the isomeric gelators was compared using rheology, and the morphologies of the xerogels were analyzed by scanning electron microscopy. These gels were used as media for metronidazole crystallization resulting in a marked habit modification of the metronidazole crystals in the drug-mimicking gels. However, crystallization in the nonmimetic isomeric gel resulted in morphologies similar to the solution state. These results indicate that the drug-mimetic gels interact with the surface of the drug crystal giving rise to new morphologies.