Metallic Carbonitride MXene Based Photonic Hyperthermia for Tumor Therapy.
Metallic Carbonitride MXene Based Photonic Hyperthermia for Tumor Therapy.
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DOI：
10.1002/smll.202200646
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发表时间：
2022-05
期刊：
影响因子：
13.3
通讯作者：
Yanhua Zhu;Xinfeng Tang;Qian Liu;Yujian Xia;Xingwu Zhai;Hui Zhang;Delong Duan;Hang Wang;Wenqi Zhan;Liang Wu;Nan Zheng;Weifu Lv;Yucai Wang;Min Zhou
中科院分区：
文献类型：
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作者：
Yanhua Zhu;Xinfeng Tang;Qian Liu;Yujian Xia;Xingwu Zhai;Hui Zhang;Delong Duan;Hang Wang;Wenqi Zhan;Liang Wu;Nan Zheng;Weifu Lv;Yucai Wang;Min Zhou
光热疗法（PTT）作为一种无创热疗，在抗癌治疗中具有很高的潜力。高效光热剂（pta）的爆炸性发展势头迅猛。MXene因其有趣的结构、出色的光动力学特性和良好的生物相容性而脱颖而出。然而，MXenes在PTT中的潜力尚未得到充分的开发。MXenes的多种化学成分为发现新的候选物质提供了巨大的机会。考虑到金属特征主要归因于金属元素，阴离子调制可能为推进具有金属性质的高效pta开辟了一条独特的途径，有望在近红外(NIR)-I和NIR- ii波段实现高光捕获。作为一个范例，选择金属碳氮化物来可视化阴离子调制的影响。利用氮的电子注入，独特的碳氮化物Ti3 C1.15 N0.85 F0.88 O0.56 (OH)0.56表现出强大的近红外吸收（在808 nm处36.6 L g-1 cm-1，在1064 nm处43.5 L g-1 cm-1），从而在体外和体内对肿瘤进行有效的光子热疗。通过对MXenes大家族的研究，这一原理验证演示提供了对原子组成和物理化学性质之间的深刻理解，这进一步巩固了MXenes在生物医学应用中的所有潜力。
Photothermal therapy (PTT) as a noninvasive hyperthermia exhibits high potential for anti-cancer treatments. The explosion of efficient photothermal agents (PTAs) keeps developing rapidly. MXene stands out due to its intriguing structures, fantastic photodynamic properties, and good biocompatibility. However, the potential of MXenes has not been sufficiently explored in PTT. Its versatile chemical compositions of MXenes provide vast opportunities to discover new candidates. Considering that the metallic feature is mainly attributed to the metal element, anionic modulation may open a distinct avenue to propel efficient PTAs with metallic nature, which is expected for high light-harvesting over near-infrared (NIR)-I and NIR-II. As a paradigm, metal carbonitride is chosen to visualize the influences of anionic modulation. Taking advantage of electron injection from nitrogen, the distinct carbonitride Ti3 C1.15 N0.85 F0.88 O0.56 (OH)0.56 exhibits a strong NIR absorption (36.6 L g-1 cm-1 at 808 nm, 43.5 L g-1 cm-1 at 1064 nm), resulting in efficient photonic hyperthermia against tumors in vitro and in vivo. Looking through a large family of MXenes, this proof-of-principle demonstration offers a deep understanding between atomic composition and physicochemical properties, which further solidifies MXenes with all the potential for biomedical applications.