Interleukin-2 production by persons with the generalized lymphadenopathy syndrome or the acquired immune deficiency syndrome.
Interleukin-2 production by persons with the generalized lymphadenopathy syndrome or the acquired immune deficiency syndrome.
复制标题
患有全身性淋巴结病综合征或获得性免疫缺陷综合征的人会产生白介素 2。
DOI：
10.1007/bf00915166
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发表时间：
1985
影响因子：
9.1
通讯作者：
Judson,FN
中科院分区：
文献类型：
--
作者：
Kirkpatrick,CH;Davis,KC;HorsburghJr,CR;Cohn,DL;Penley,K;Judson,FN
我们用植物血凝素刺激的外周血单核细胞检测了27名异性恋者、43名无症状男同性恋者、34名患有全身性淋巴结病综合征（GLS）的男同性恋者和21名获得性免疫缺陷综合征（AIDS）患者的白细胞介素-2 （IL-2）的产生。无症状的异性恋和同性恋受试者产生相当数量的IL-2，但11名机会性感染的艾滋病患者中有8名和3名同时患有机会性感染和卡波西肉瘤的艾滋病患者中有2名无法产生可检测到的IL-2；所有7名只有卡波西肉瘤的艾滋病患者都产生了IL-2。艾滋病患者产生的IL-2滴度与辅助性T淋巴细胞（Leu 3a+细胞）的百分比相关，而与抑制性T淋巴细胞（Leu 2a+细胞）的百分比无关。这一观察结果被解释为艾滋病患者无法产生IL-2很可能是由于产生IL-2的细胞耗竭，尽管不能排除t细胞功能异常。此外，在8名不能产生IL-2的艾滋病患者中，有3名产生了抑制IL-2依赖性细胞在IL-2存在下生长的上清液。这些观察结果表明，内源性IL-2产生的测量可能在选择患者接受IL-2治疗时很重要。
We measured production of interleukin-2 (IL-2) by phytohemagglutinin-stimulated peripheral blood mononuclear cells from 27 heterosexual persons, 43 asymptomatic homosexual men, 34 homosexual men with generalized lymphadenopathy syndrome (GLS), and 21 patients with acquired immune deficiency syndrome (AIDS). Asymptomatic heterosexual and homosexual subjects produced comparable amounts of IL-2, but 8 of 11 AIDS patients with opportunistic infections and two of three AIDS patients with both opportunistic infections and Kaposi's sarcoma failed to produce detectable amounts of IL-2; all seven AIDS patients with only Kaposi's sarcoma produced IL-2. The titer of IL-2 produced by the AIDS patients correlated with the percentage of helper T lymphocytes (Leu 3a+cells) but not with the percentage of suppressor T lymphocytes (Leu 2a+cells). This observation is interpreted as indicating that failure to produce IL-2 by AIDS patients is most likely due to depletion of IL-2-producing cells, although an abnormality of T-cell function has not been excluded. In addition, three of eight AIDS patients who did not produce IL-2 produced supernatants that inhibited growth of IL-2-dependent cells in the presence of IL-2. These observations suggest that measurement of endogenous IL-2 production may be important in selecting patients for therapy with IL-2.