A new job for ancient extracellular matrix proteins: Hemicentins stabilize cleavage furrows.
A new job for ancient extracellular matrix proteins: Hemicentins stabilize cleavage furrows.
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DOI：
10.4161/cib.4.4.15324
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发表时间：
2011-07-01
影响因子：
--
通讯作者：
Vogel, Bruce E
中科院分区：
文献类型：
--
作者：
Xu, Xuehong;Vogel, Bruce E
细胞外基质 (ECM) 蛋白和跨膜受体之间的相互作用介导细胞迁移、粘附、分化和极化过程中细胞形状的变化。细胞分裂是细胞分裂的最后一步，因为细胞利用由肌动蛋白和肌球蛋白组成的收缩环将一个细胞分成两个。在分割过程中，新生膜内陷形成一个新的细胞外空间，称为卵裂沟。尽管细胞分裂过程中细胞形状发生了巨大变化，但现有模型并未考虑 ECM 的作用。在最近的一篇论文中，我们表明半星素在秀丽隐杆线虫生殖细胞和小鼠胚胎卵裂球的卵裂沟中组装。 Hemicentin 耗尽会导致膜不稳定、卵裂沟收缩和胞质分裂失败。数据表明，半中心素和其他 ECM 蛋白在多种细胞类型的胞质分裂过程中稳定裂解沟。
Interactions between extracellular matrix (ECM) proteins and transmembrane receptors mediate changes in cell shape during cell migration, adhesion, differentiation and polarization. Cytokinesis is the final step in cell division as cells employ a contractile ring composed of actin and myosin to partition one cell into two. During the partition process, an invagination in nascent membrane forms a new extracellular space called the cleavage furrow. Despite the dramatic changes in cell shape during cytokinesis, existing models include no role for the ECM. In a recent paper, we show that hemicentins assemble in the cleavage furrow of C. elegans germ cells and mouse embryo blastomeres. Hemicentin depletion results in membrane destabilization, cleavage furrow retraction and cytokinesis failure. The data suggest that hemicentins and other ECM proteins stabilize the cleavage furrow during cytokinesis of multiple cell types.