Synthesis and Characterization of Crosslinked Maleyl Chitosan Microspheres Prepared by Coacervation Technique
Synthesis and Characterization of Crosslinked Maleyl Chitosan Microspheres Prepared by Coacervation Technique
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DOI：
10.1080/10601320902797756
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发表时间：
2009-03
期刊：
影响因子：
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通讯作者：
L. Lacerda;H. K. Stulzer;A. Parize;B. L. Horst;V. Fávere;M. Laranjeira
中科院分区：
文献类型：
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作者：
L. Lacerda;H. K. Stulzer;A. Parize;B. L. Horst;V. Fávere;M. Laranjeira
采用凝聚法制备了不同取代度的交联壳聚糖微球，并用马来酸酐进行化学改性。采用红外光谱、核磁共振谱、元素分析、溶胀度、热重分析和扫描电镜等手段对所得体系进行了表征。在表征中获得的结果表明单酰胺和单羧酸基团的形成。改性壳聚糖微球在pH 1.2下呈现高溶胀度，在250 °C和330°C之间呈现一个质量损失事件，并且呈现球形。总之，该系统被证明是一个潜在的候选人，用于控制药物输送。
Crosslinked chitosan microspheres with different substitution degrees were prepared by the coacervation technique and chemically modified with maleic anhydride. The resultant systems were characterized by FT-IR, 13C-NMR, elemental analysis, degree of swelling, thermogravimetry and scanning electron microscopy. The results obtained in the characterization suggest the formation of monoamide and monocarboxylic acid groups. The modified chitosan microspheres presented a high swelling degree at pH 1.2, one mass loss event at between 250 and 330°C, and a spherical shape. In summary, this system was shown to be a potential candidate for use in controlled drug delivery.