Iodine-Catalyzed Facile Approach to Sulfones Employing TosMIC as a Sulfonylating Agent
Iodine-Catalyzed Facile Approach to Sulfones Employing TosMIC as a Sulfonylating Agent
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DOI：
10.1021/acs.orglett.7b00896
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发表时间：
2017-05-19
期刊：
影响因子：
5.2
通讯作者：
Yallapragada, Lakshmi Prapurna
中科院分区：
文献类型：
--
作者：
Kadari, Lingaswamy;Palakodety, Radha Krishna;Yallapragada, Lakshmi Prapurna
描述了一种新的碘催化的多种烯烃和炔烃的官能化，以及肉桂酸和丙酚酸的直接脱羧基官能化，从而提供了各种乙烯基、烯丙基和β-碘乙烯基砜的途径。这种使用廉价分子碘作为催化剂的简单、高效和环境友好的方法展示了一种合成高价值砜的通用方案，使其在合成和药物化学方面都具有吸引力。
A novel iodine-catalyzed functionalization of a variety of olefins and alkynes and direct decarboxylative functionalization of cinnamic and propiolic acids with TosMIC to provide access to various vinyl, allyl, and beta-iodo vinylsulfones is described. This simple, efficient, and environmentally benign approach employing inexpensive molecular iodine as a catalyst demonstrates a versatile protocol for the synthesis of highly valuable sulfones, rendering it attractive to both synthetic and medicinal chemistry.