Transgenerational epigenetic imprints on mate preference
Transgenerational epigenetic imprints on mate preference
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DOI：
10.1073/pnas.0610410104
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发表时间：
2007-04-03
影响因子：
11.1
通讯作者：
Skinner, Michael K.
中科院分区：
文献类型：
--
作者：
Crews, David;Gore, Andrea C.;Skinner, Michael K.
内分泌干扰化学品（EDC）的环境污染可能对生殖系产生表观遗传效应（通过DNA甲基化），并在后代中促进疾病。在自然种群中，在繁殖季节，两性都可能遇到受影响和未受影响的个体，任何吸引力的减少都可能危及繁殖成功。在这里，我们研究了雄性和雌性大鼠的交配偏好，其祖细胞已被处理与抗雄激素杀菌剂烯效唑。这种影响是性别特异性的，我们表明，女性三代删除曝光歧视，更喜欢男性谁没有曝光的历史，而同样的表观遗传印记的男性不表现出这样的偏好。观察结果表明，内分泌干扰物的后果不仅是跨代的，而且可以是“跨种群的”，因为在许多哺乳动物物种中，雄性是分散的性别。这一结果表明，表观遗传跨代遗传的EDC行动代表了一个不受重视的力量在性选择。我们的观察为表观遗传学作为进化决定因素的作用提供了直接的实验证据。
Environmental contamination by endocrine-disrupting chemicals (EDC) can have epigenetic effects (by DNA methylation) on the germ line and promote disease across subsequent generations. In natural populations, both sexes may encounter affected as well as unaffected individuals during the breeding season, and any diminution in attractiveness could compromise reproductive success. Here we examine mate preference in male and female rats whose progenitors had been treated with the antiandrogenic fungicide vinclozolin. This effect is sex-specific, and we demonstrate that females three generations removed from the exposure discriminate and prefer males who do not have a history of exposure, whereas similarly epigenetically imprinted males do not exhibit such a preference. The observations suggest that the consequences of EDCs are not just transgenerational but can be "transpopulational", because in many mammalian species, males are the dispersing sex. This result indicates that epigenetic transgenerational inheritance of EDC action represents an unappreciated force in sexual selection. Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution.