Effects of warming yang and invigorating qi prescription on renin-angiotensin-aldosterone system in rats with heart failure after myocardial infarction
Effects of warming yang and invigorating qi prescription on renin-angiotensin-aldosterone system in rats with heart failure after myocardial infarction
复制标题
温阳补气方对心肌梗死后心力衰竭大鼠肾素-血管紧张素-醛固酮系统的影响
DOI：
10.1590/1678-457x.21616
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发表时间：
2017-04-01
影响因子：
--
通讯作者：
Li，Zhiwei
中科院分区：
文献类型：
--
作者：
Han，Lihua;Wang，Zhentao;Li，Zhiwei
研究温阳益气方对心肌梗死后心力衰竭大鼠肾素-血管紧张素-醛固酮系统（RAAS）的影响。将126只大鼠随机分为模型组、假手术组、温阳补气组、温阳+补气组、地高辛、卡托普利组分别治疗。干预6、8、10周后计算左室射血分数（LVEF），测定血浆肾素、血管紧张素II、醛固酮水平。结果显示，在6、8、10周后，温阳、补气组、温阳+补气组和卡托普利组LVEF显著高于模型组（P < 0.05），温阳、补气组、温阳+补气组和卡托普利组血浆肾素、血管紧张素II和醛固酮水平显著低于模型组（P < 0.05）。益气组、温阳+益气组和卡托普利组10周后肾素血管紧张素II、醛固酮水平显著低于6周后（P < 0.05）；卡托普利组治疗10周后醛固酮水平显著低于治疗6周后（P < 0.05）。温阳益气方能改善心梗后心力衰竭大鼠LVEF，可能与抑制RAAS激活有关。
This study investigated the effects of warming yang and invigorating qi prescription on renin-angiotensin-aldosterone system (RAAS) in rats with heart failure after myocardial infarction. 126 rats were randomly divided into model group, sham operation, warming yang, invigorating qi, warming yang+invigorating qi, digoxin and captopril group for respective treatment. After intervention for 6, 8 and 10 weeks, the left ventricular ejection fraction (LVEF) was calculated, and the plasma renin, angiotensin II and aldosterone levels were measured. Results showed that, after 6, 8 and 10 weeks, LVEF in warming yang, invigorating qi, warming yang+invigorating qi and captopril group was significantly higher than model group (P < 0.05), and the plasma renin, angiotensin II and aldosterone levels in warming yang, invigorating qi, warming yang+invigorating qi and captopril groups were significantly lower than model group (P < 0.05). Renin angiotensin II and aldosterone levels in invigorating qi, warming yang+invigorating qi and captopril groups after 10 weeks was significantly lower than after 6 weeks (P < 0.05); aldosterone level in captopril groups after 10 weeks was significantly lower than after 6 weeks (P < 0.05). Warming yang and invigorating qi prescription can improve LVEF in rats with heart failure after myocardial infarction, which may be related with the inhibition of RAAS activation.