Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer
Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer
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DOI：
10.1007/s00408-004-2521-4
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发表时间：
2005-01-01
期刊：
影响因子：
5
通讯作者：
Fukurchi, Y
中科院分区：
文献类型：
--
作者：
Shimanuki, Y;Takahashi, K;Fukurchi, Y
尽管血管内皮生长因子（VEGF）和基质金属蛋白酶（MMP）-9参与各种癌症的血管生成，但这些分子在非小细胞肺癌（NSCLC）中的术前血清浓度的临床效用尚未阐明。在这项研究中，我们确定了手术前血清中VEGF，MMP-9和各种其他肿瘤标志物的浓度，并将结果与肿瘤内血管进行比较，以分离出一种有价值的标志物，用于确定NSCLC血管生成的预测。在这些分子和血清肿瘤标志物中，循环血清VEGF被鉴定为与切除肿瘤标本的微血管密度（MVD）显著相关。此外，低VEGF水平（小于或等于326 ng/ml）患者的总生存率显著高于高VEGF水平（> 326 ng/ml）患者，而低MMP-9水平（大于或等于189 ng/ml）患者和高MMP-9水平（> 189 ng/ml）患者的总生存率相似。结论：术前血清VEGF浓度可作为预测NSCLC患者肿瘤内血管生成及预后的最有价值的指标。
Although vascular endothelial growth factor (VEGF) and matrix metalloprotemase (MMP)-9 are involved in angiogenesis of various cancers, clinical utility of preoperative serum concentration of these molecules in non-small cell lung cancer (NSCLC) has not yet been elucidated. In this study, we determined the concentration of VEGF, MMP-9 and various other tumor markers in serum prior to surgery and evaluated the results compared with intratumoral vasculature to isolate a valuable marker in determining the prediction of angiogenesis in NSCLC. Among these molecules and serum tumor markers, circulating serum VEGF was identified to markedly correlate with microvessel density (MVD) of the resected tumor specimens. Moreover, overall survival of patients with low VEGF levels ( less than or equal to 326 ng/ml) was significantly greater than that of patients with high VEGF levels ( > 326 ng/ml), while patients with low MMP-9 levels ( greater than or equal to 189 ng/ml) and those with high MMP-9 levels (> 189 ng/ml) revealed similar overall survival. Conclusively, preoperative concentration of serum VEGF may be the most valuable marker in the prediction of intratumoral angiogenesis and prognosis of patients with NSCLC.