Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator
Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator
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DOI：
10.1063/1.2789694
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发表时间：
2007-09-17
影响因子：
4
通讯作者：
Manalis, Scott R.
中科院分区：
文献类型：
--
作者：
Godin, Michel;Bryan, Andrea K.;Manalis, Scott R.
我们演示了使用悬浮微通道谐振器的质量，密度和大小的细胞和纳米粒子的测量。单个颗粒的质量被量化为瞬态频率偏移，而颗粒通过嵌入在共振悬臂中的微流体通道。从这些数据得到的质量直方图揭示了不均匀大小的颗粒群的分布。从在不同载液中进行的测量推断颗粒密度，因为颗粒的频移与相对于置换溶液的质量差成比例。我们已经表征了聚苯乙烯颗粒、大肠杆菌和人红细胞的密度，分辨率低至10（-4）g/cm（3）。(c)2007年，美国物理学会。
We demonstrate the measurement of mass, density, and size of cells and nanoparticles using suspended microchannel resonators. The masses of individual particles are quantified as transient frequency shifts, while the particles transit a microfluidic channel embedded in the resonating cantilever. Mass histograms resulting from these data reveal the distribution of a population of heterogeneously sized particles. Particle density is inferred from measurements made in different carrier fluids since the frequency shift for a particle is proportional to the mass difference relative to the displaced solution. We have characterized the density of polystyrene particles, Escherichia coli, and human red blood cells with a resolution down to 10(-4) g/cm(3). (c) 2007 American Institute of Physics.