Association between rosacea and cardiometabolic disease: A systematic review and meta-analysis
Association between rosacea and cardiometabolic disease: A systematic review and meta-analysis
复制标题
红斑痤疮与心脏代谢疾病之间的关联：系统评价和荟萃分析
DOI：
10.1016/j.jaad.2020.04.113
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发表时间：
2020-11-01
影响因子：
13.8
通讯作者：
Li, Ji
中科院分区：
文献类型：
--
作者：
Chen, Qi;Shi, Xiao;Li, Ji
背景：酒渣鼻是一种慢性炎症性皮肤病，与多种全身性疾病有关。目的：通过系统评价和荟萃分析，评价酒渣鼻与心脏代谢病（cardiometabolic disease，CMD）的相关性。方法：全面检索PubMed、Embase、科克伦图书馆和Web of Science数据库中2019年10月16日之前发表的研究。合并的风险比或标准化的平均differentiations.Results：13项研究被纳入，代表50,442例酒渣鼻患者。酒渣鼻患者血脂异常、高血压、总胆固醇、低密度脂蛋白、甘油三酯、收缩压、舒张压和空腹血糖的患病率较高。酒渣鼻与缺血性心脏病，中风，糖尿病，和高密度lipoprotein.Limitations：没有亚组分析可以进行根据亚型和严重程度的酒渣鼻。结论：酒渣鼻显示相关性与高血压和血脂异常，但不与缺血性心脏病，中风，或糖尿病。我们提倡在酒渣鼻患者中筛查CMD指标，这可能有助于疾病早期的诊断和适当的治疗。
Background: Rosacea is recognized as a chronic inflammatory cutaneous disorder associated with multiple systemic illnesses. However, the association between rosacea and cardiometabolic disease (CMD) remains controversial.Objective: To evaluate the association between rosacea and CMD by a systematic review and meta-analysis.Methods: A comprehensive search of studies published before October 16, 2019, was performed in databases of PubMed, Embase, Cochrane Library, and Web of Science. The pooled risk ratios or standardized mean differences were calculated.Results: Thirteen studies were included, representing 50,442 patients with rosacea. Patients with rosacea had higher prevalence of dyslipidemia, higher prevalence of hypertension, higher total cholesterol, higher low-density lipoprotein, higher triglycerides, higher systolic blood pressure, higher diastolic blood pressure, and higher fasting blood glucose. Rosacea was not associated with ischemic heart disease, stroke, diabetes, and high-density lipoprotein.Limitations: No subgroup analysis could be performed according to the subtypes and severity of rosacea.Conclusions: Rosacea showed a correlation with hypertension and dyslipidemia but not with ischemic heart disease, stroke, or diabetes. We advocate screening for CMD indicators among patients with rosacea, which may be helpful for diagnosis and appropriate treatment at an early stage of disease.