THE POTENTIAL ROLE OF SALT ABUSE ON THE RISK FOR KIDNEY-STONE FORMATION
THE POTENTIAL ROLE OF SALT ABUSE ON THE RISK FOR KIDNEY-STONE FORMATION
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DOI：
10.1016/s0022-5347(17)35468-x
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发表时间：
1993-08-01
影响因子：
6.6
通讯作者：
PAK, CYC
中科院分区：
文献类型：
--
作者：
SAKHAEE, K;HARVEY, JA;PAK, CYC
通过评估高钠饮食对尿液中结石形成盐结晶的影响，评估高钠饮食的肾结石形成风险。14名正常受试者参加了2个阶段的研究，每个阶段持续10天，包括低钠阶段（基础代谢饮食含有50 mmol.钠/天）和高钠阶段（基础饮食加250 mmol.氯化钠/天）。高钠摄入显著增加尿钠（34 +/- 12至267 +/- 56 mmol）。每天），钙（12.73 +/- 1.03至3.93 +/- 1.51 mmol.每天）和pH值（5.79 +/- 0.44至6.15 +/- 0.25），并显著降低尿柠檬酸盐（3.14 +/- 1.19至2.52 +/- 0.83 mmol.每天）。动脉化静脉血碳酸氢盐和总血清二氧化碳浓度显着下降，在高钠饮食，而血清氯化物浓度增加。然而，未检测到动脉化静脉pH值的变化。因此，高钠摄入不仅增加钙排泄，而且增加尿pH值和减少柠檬酸盐排泄。后者的影响可能是由于钠诱导的碳酸氢尿和血清碳酸氢盐浓度显着下降，分别与这些变化，磷酸钙（透钙磷石）和草酸钙的尿饱和度增加，抑制剂活性对草酸钙结晶（形成产品）下降。高钠饮食的净效应是尿中钙盐结晶的倾向增加。
The kidney stone-forming risk of a high sodium diet was evaluated by assessing the effect of such a diet on the crystallization of stone-forming salts in urine. Fourteen normal subjects participated in 2 phases of study of 10 days duration each, comprising a low sodium phase (basal metabolic diet containing 50 mmol. sodium per day) and a high sodium phase (basal diet plus 250 mmol. sodium chloride per day). The high sodium intake significantly increased urinary sodium (34 +/- 12 to 267 +/- 56 mmol. per day), calcium (12.73 +/- 1.03 to 3.93 +/- 1.51 mmol. per day) and pH (5.79 +/- 0.44 to 6.15 +/- 0.25), and significantly decreased urinary citrate (3.14 +/- 1.19 to 2.52 +/- 0.83 mmol. per day). Arterialized venous blood bicarbonate and total serum carbon dioxide concentrations decreased significantly during the high sodium diet, whereas serum chloride concentration increased. However, no change in arterialized venous pH was detected. Thus, a high sodium intake not only increased calcium excretion, but also increased urinary pH and decreased citrate excretion. The latter effects are probably due to sodium-induced bicarbonaturia and a significant decrease in serum bicarbonate concentration, respectively.Commensurate with these changes, the urinary saturation of calcium phosphate (brushite) and monosodium urate increased, and the inhibitor activity against calcium oxalate crystallization (formation product) decreased. The net effect of a high sodium diet was an increased propensity for the crystallization of calcium salts in urine.