Matrix metalloproteinase expression and localization in turkey (Meleagris gallopavo) during the endochondral ossification process.
Matrix metalloproteinase expression and localization in turkey (Meleagris gallopavo) during the endochondral ossification process.
复制标题
软骨内骨化过程中火鸡（Meleagris gallopavo）基质金属蛋白酶的表达和定位。
DOI：
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发表时间：
2007
影响因子：
3.3
通讯作者：
E. M. Ornan
中科院分区：
文献类型：
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作者：
S. Simsa;O. Genina;E. M. Ornan
脊椎动物长骨是由软骨内成骨形成的，这一过程伴随着细胞外基质合成和重塑的变化，主要由基质金属蛋白酶（MMP）完成。我们首次在火鸡胚胎期和幼年期的生长板中研究了5个已知对软骨内成骨很重要的MMP家族成员的时空表达模式。MMP-2表达于增殖区，MMP-3、MMP-9、MMP-13表达于血管内膜细胞；肥大软骨细胞中也检测到MMP-13。在生长板的保留区检测到MMP-16的表达。这些结果提供了火鸡MMP的详细调查，作为该主题进一步研究的数据源（地图集）。
Vertebrate long bones are formed by endochondral ossification, a process accompanied by changes in extracellular matrix synthesis and remodeling, performed mainly by the matrix metalloproteinases (MMP). The temporal/spatial expression patterns of 5 members of the MMP family known to be important for endochondral ossification were studied, for the first time, in the turkey growth plate during embryonic and juvenile stages. The expression of MMP-2 was detected in the proliferative zone, MMP-3, MMP-9, and MMP-13 in cells lining the blood vessels; MMP-13 was also detected in hypertrophic chondrocytes. The MMP-16 expression was detected in the reserve zone of the growth plate. These results present a detailed survey of turkey MMP, serving as a data source (atlas) for further studies in this subject.