Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal.
Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal.
复制标题
视网膜变性的神经保护策略：通过抑制 mTOR 信号来抑制 ER 应激诱导的细胞死亡。
DOI：
10.3390/ijms18010201
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发表时间：
2017-01-19
影响因子：
5.6
通讯作者：
Li GY
中科院分区：
文献类型：
--
作者：
Fan B;Sun YJ;Liu SY;Che L;Li GY
视网膜是一种特殊的感觉器官，对人眼的光检测和视觉形成是必不可少的。遗传性视网膜变性是一组不同类型的眼病，最终会导致永久性视力丧失。UPR(未折叠蛋白反应)和ER(内质网)应激在视网膜退行性疾病的病理机制中起重要作用。MTOR(雷帕霉素的哺乳动物靶标)激酶作为信号中枢，控制着许多细胞过程，包括蛋白质合成、RNA翻译、内质网应激和细胞凋亡。在这里，抑制mTOR信号可以抑制视网膜退行性疾病中内质网应激诱导的细胞死亡这一假设被讨论。该综述综述了mTOR信号对视网膜退行性疾病中蛋白质错误折叠和基因突变引起的内质网应激的影响，并强调了潜在的神经保护策略和治疗意义。
The retina is a specialized sensory organ, which is essential for light detection and visual formation in the human eye. Inherited retinal degenerations are a heterogeneous group of eye diseases that can eventually cause permanent vision loss. UPR (unfolded protein response) and ER (endoplasmic reticulum) stress plays an important role in the pathological mechanism of retinal degenerative diseases. mTOR (the mammalian target of rapamycin) kinase, as a signaling hub, controls many cellular processes, covering protein synthesis, RNA translation, ER stress, and apoptosis. Here, the hypothesis that inhibition of mTOR signaling suppresses ER stress-induced cell death in retinal degenerative disorders is discussed. This review surveys knowledge of the influence of mTOR signaling on ER stress arising from misfolded proteins and genetic mutations in retinal degenerative diseases and highlights potential neuroprotective strategies for treatment and therapeutic implications.